Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/5729
A PATOLOGIA DA ESQUISTOSSOMOSE MANSONI NO COELHO
Esquistossomose mansoni/patologia
Animais
Modelos Animais de Doenças
Feminino
Fígado/ultraestrutura
Cirrose Hepática Experimental/patologia
Masculino
Veia Porta/ultraestrutura
Coelhos
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract
The pathology of schistosomiasis mansoni in rabbits was studied with special consideration to worm burden and duration of infection. Heavy and prolonged infections resulted in severe changes involving the intrahepatic portal vein branches, such as: polypoid endophlebitis, granulomatous endophlebitis and, later on, vascular occlusion and recanalization, vascular ectasia, fibrosis and hyalinization of the endothelial polyps. Living and dead adult worms, rather than the mature eggs, were the main pathogenetic factors. For some time the lesions tend to be limited to the portal vein branches, not extending to the periportal tissues, but, after 8 to 10 months, variable degree of portal, septal and intra-parenchymal fibrosis can be formed. However, both vascular and fibrotic changes in the liver had a focal distribution and therefore did not appear to cause portal hypertension and had no resemblance to the human pathology seen in cases of hepatosplenic schistosomiasis. Pathology of schistosomiasis in rabbits has peculiar aspects, which are worthwhile studying, since the model can be of interest for investigations, especially concerning the immunology and immunopathology of schistosomiasis mansoni.
DeCS
Hepatopatias Parasitárias/patologiaEsquistossomose mansoni/patologia
Animais
Modelos Animais de Doenças
Feminino
Fígado/ultraestrutura
Cirrose Hepática Experimental/patologia
Masculino
Veia Porta/ultraestrutura
Coelhos
Share