Author | Useche, Yerly | |
Author | Pérez, Ana Rosa | |
Author | Meis, Juliana de | |
Author | Bonomo, Adriana | |
Author | Savino, Wilson | |
Access date | 2023-02-26T21:54:10Z | |
Available date | 2023-02-26T21:54:10Z | |
Document date | 2022 | |
Citation | USECHE, Yerly et al. Central nervous system commitment in Chagas disease. Frontiers in Immunology, 13. 975106, p. 1 - 9, Nov. 2022. | en_US |
ISSN | 1664-3224 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/57140 | |
Language | eng | en_US |
Publisher | Frontiers Media | en_US |
Rights | open access | |
Subject in Portuguese | Doença de Chagas | en_US |
Subject in Portuguese | Sistema NerVoso Central | en_US |
Subject in Portuguese | Interações neuroimunes | en_US |
Subject in Portuguese | Encefalite | en_US |
Subject in Portuguese | Inflamação cerebral | en_US |
Subject in Portuguese | Transmissão oral do Trypanosoma cruzi | en_US |
Title | Central nervous system commitment in Chagas disease | en_US |
Type | Article | en_US |
DOI | 10.3389/fimmu.2022.975106 | |
Abstract | The involvement of the central nervous system (CNS) during human acute and
chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is
a frequent finding during the acute infection, while during chronic phase the
CNS involvement is often accompanied by behavioral and cognitive
impairments. In the same vein, several studies have shown that rodents
infected with Trypanosoma cruzi (T. cruzi) display behavior abnormalities,
accompanied by brain inflammation, in situ production of pro-inflammatory
cytokines and parasitism in diverse cerebral areas, with involvement of
microglia, macrophages, astrocytes, and neurons. However, the mechanisms
used by the parasite to reach the brain remain now largely unknown. Herein we
discuss the evidence unravelling the CNS involvement and complexity of
neuroimmune interactions that take place in acute and chronic CD. Also, we
provide some clues to hypothesize brain infections routes in human and
experimental acute CD following oral infection by T. cruzi, an infection route
that became a major CD related public health issue in Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Institute of Clinical and Experimental Immunology of Rosario (IDICER CONICET UNR), Rosario, Argentina / Center for Research and Production of Biological Reagents (CIPReB), Faculty of Medical Sciences National University of Rosario, Rosario, Argentina. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Rede de Pesquisa no Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Rede de Pesquisa no Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Rede de Pesquisa no Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Chagas disease | en_US |
Subject | Central nervous system | en_US |
Subject | Neuroimmune interactions | en_US |
Subject | Encephalitis | en_US |
Subject | Brain inflammation | en_US |
Subject | Oral Trypanosoma cruzi transmission | en_US |