Author | Bortolini, Miguel Junior Sordi | |
Author | Petriz, Bernardo | |
Author | Mineo, José Roberto | |
Author | Resende, Rafael de Oliveira | |
Access date | 2023-02-11T13:08:09Z | |
Available date | 2023-02-11T13:08:09Z | |
Document date | 2022 | |
Citation | BORTOLINI, Miguel Junior Sordi et al. Why Physical Activity Should Be Considered in Clinical Trials for COVID-19 Vaccines: A Focus on Risk Groups. International Journal of Environmental Research and Public Health, v. 19, 1853, p. 1 - 10, 2022. | en_US |
ISSN | 1660-4601 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/57020 | |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | |
Subject in Portuguese | COVID-19 | en_US |
Subject in Portuguese | Atividade física | en_US |
Subject in Portuguese | SARS-CoV-2 | en_US |
Subject in Portuguese | Vacina | en_US |
Subject in Portuguese | Testes clínicos | en_US |
Title | Why Physical Activity Should Be Considered in Clinical Trials for COVID-19 Vaccines: A Focus on Risk Groups | en_US |
Type | Article | |
DOI | 10.3390/ijerph19031853 | |
Abstract | Since the World Health Organization declared the global COVID-19 state of emergency in
early 2020, several vaccine candidates have emerged to control SARS-CoV-2, and some of them have
been approved and implemented in vaccination campaigns worldwide. Although clinical trials for
these vaccines have been carried out using highly controlled methods with accurate immunological
tests, clinical questionnaires did not include questions concerning the physical activity profile among
volunteers. It has been well established that physical activity plays a pivotal role in the immune
response after vaccination, led by the activation of cytokines, antibodies, and cells. This concept
should have been considered when evaluating the efficacy of COVID-19 vaccine candidates, particularly in elderly and obese people. Here, we discuss data from the literature providing strong
evidence regarding the importance of analyzing physical activity parameters to improve the accuracy
of clinical trials on assessing the efficacy of vaccine candidates. | en_US |
Affilliation | Universidade Federal do Acre. Centro de Ciências da Saúde e do Desporto. Laboratório de Imunologia Translacional. Rio Branco, Acre, Brasil. | en_US |
Affilliation | Centro Universitário UDF. Laboratório de Fisiologia Molecular do Exercício. Brasílila, DF, Brasil. | en_US |
Affilliation | Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Imunoparasitologia “Dr. Mário Endsfeldz Camargo”. Uberlândia, MG, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Imunologia Clínica e Alergia. Uberlândia, MG, Brasil. | en_US |
Subject | Physical activity | en_US |
Subject | COVID-19 | en_US |
Subject | SARS-CoV-2 | en_US |
Subject | Vaccine | en_US |
Subject | Clinical trials | en_US |