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https://www.arca.fiocruz.br/handle/icict/56929
MAHPIC MALARIA SYSTEMS BIOLOGY DATA FROM PLASMODIUM CYNOMOLGI SPOROZOITE LONGITUDINAL INFECTIONS IN MACAQUES
Author
DeBarry, Jeremy D.
Nural, Mustafa V.
Pakala, Suman B.
Nayak, Vishal
Warrenfeltz, Susanne
Humphrey, Jay
Lapp, Stacey A.
Cabrera-Mora, Monica
Brito, Cristiana Ferreira Alves de
Jiang, Jianlin
Saney, Celia L.
Hankus, Allison
Stealey, Hannah M.
DeBarry, Megan B.
Lackman, Nicolas
Legall, Noah
Lee, Kevin
Tang, Yan
Gupta, Anuj
Trippe, Elizabeth D.
Bridger, Robert R.
Weatherly, Daniel Brent
Peterson, Mariko S.
Jiang, Xuntian
Tran, ViLinh
Uppal, Karan
Fonseca, Luis L.
Joyner, Chester J.
Karpuzoglu, Ebru
Cordy, Regina J.
Meyer, Esmeralda V. S.
Wells, Lance L.
Ory, Daniel S.
Lee, F. Eun-Hyung
Tirouvanziam, Rabindra
Gutiérrez, Juan B.
Ibegbu, Chris
Lamb, Tracey J.
Pohl, Jan
Pruett, Sarah T.
Jones, Dean P.
Styczynski, Mark P.
Voit, Eberhard O.
Moreno, Alberto
Galinski, Mary R.
Nural, Mustafa V.
Pakala, Suman B.
Nayak, Vishal
Warrenfeltz, Susanne
Humphrey, Jay
Lapp, Stacey A.
Cabrera-Mora, Monica
Brito, Cristiana Ferreira Alves de
Jiang, Jianlin
Saney, Celia L.
Hankus, Allison
Stealey, Hannah M.
DeBarry, Megan B.
Lackman, Nicolas
Legall, Noah
Lee, Kevin
Tang, Yan
Gupta, Anuj
Trippe, Elizabeth D.
Bridger, Robert R.
Weatherly, Daniel Brent
Peterson, Mariko S.
Jiang, Xuntian
Tran, ViLinh
Uppal, Karan
Fonseca, Luis L.
Joyner, Chester J.
Karpuzoglu, Ebru
Cordy, Regina J.
Meyer, Esmeralda V. S.
Wells, Lance L.
Ory, Daniel S.
Lee, F. Eun-Hyung
Tirouvanziam, Rabindra
Gutiérrez, Juan B.
Ibegbu, Chris
Lamb, Tracey J.
Pohl, Jan
Pruett, Sarah T.
Jones, Dean P.
Styczynski, Mark P.
Voit, Eberhard O.
Moreno, Alberto
Galinski, Mary R.
Affilliation
Institute of Bioinformatics. University of Georgia.Athens, GA, USA
Institute of Bioinformatics. University of Georgia, Athens, GA, USA
Department of Medicine. Vanderbilt University Medical Center. Nashville, TN, USA/ Institute of Bioinformatics. University of Georgia, Athens, GA, USA
Cancer Data Science Initiatives. Frederick National Laboratory for Cancer Research. Frederick, MD, USA/Institute of Bioinformatics. University of Georgia, Athens, GA, USA
Center for Tropical and Emerging Global Diseases. University of Georgia. Athens, GA, USA
Center for Tropical and Emerging Global Diseases. University of Georgia. Athens, GA, USA/Institute of Bioinformatics, University of Georgia. Athens, GA, USA
Department of Pediatrics. Emory University School of Medicine. Atlanta, GA, USA/Emory Vaccine Center. Yerkes/Emory National Primate Research Center. Emory University, Atlanta, GA, USA
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine. Department of Medicine. Emory University School of Medicine. Atlanta, GA, USA/Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil/Emory Vaccine Center. Yerkes. Atlanta, GA, USA/Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Present address: Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA/Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Senior Public Health Informaticist. MITRE Corp, Atlanta, GA, USA/ Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Department of Biomedical Engineering. University of Texas at Austin. Austin, TX, USA/Institute of Bioinformatics. University of Georgia. Athens, GA, USA
Institute of Bioinformatics, University of Georgia. Athens, GA, USA
Institute of Bioinformatics, University of Georgia, Athens, GA, USA
Interdisciplinary Disease Ecology Across Scales Research Traineeship Program. Institute of Bioinformatics. Center for the Ecology of Infectious Diseases. University of Georgia. Athens, GA, USA/Institute of Bioinformatics. University of Georgia. Athens, GA, USA
Center for Integrative Genomics. School of Biology. Georgia Institute of Technology. Atlanta, GA, USA
Department of Medicine. Brigham and Women’s Hospital. Harvard Medical School. Boston, MA, USA/School of Chemical & Biomolecular Engineering. Georgia Institute of Technology. Atlanta, GA, USA
The Wallace H. Coulter Department of Biomedical Engineering. Georgia Institute of Technology and Emory University. Atlanta, GA, USA
Federal Drug Administration. Silver Spring, MD, USA/Institute of Bioinformatics. University of Georgia. Athens.GA, USA
Complex Carbohydrate Research Center. Department of Biochemistry. University of Georgia. Athens, GA, USA
Complex Carbohydrate Research Center. Department of Biochemistry. University of Georgia, Athens. GA, USA
Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA
Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA
Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA
Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA/The Wallace H. Coulter Department of Biomedical Engineering. Georgia Institute of Technology and Emory University. Atlanta, GA, USA
Center for Tropical and Emerging Global Disease. University of Georgia. Athens, GA, USA/ Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Department of Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA, USA/ Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Department of Biology. Wake Forest University. Winston Salem, NC, USA/Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Institutional Animal Care and Use Committee, Research Compliance and Research Integrity Office, Emory University, Atlanta, GA, USA// Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Complex Carbohydrate Research Center. Department of Biochemistry. University of Georgia, Athens. GA, USA
Casma Therapeutics, Cambridge, MA, USA/Division of Endocrinology. Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA
Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. Lowance Center for Human Immunology. Emory University. Atlanta, GA, USA
Department of Pediatrics. Emory University School of Medicine. Atlanta, GA, USA
University of Texas at San Antonio. San Antonio, TX, USA/Institute of Bioinformatics. University of Georgia. Athens, GA, USA/Department of Mathematics, Institute of Bioinformatics, University of Georgia, Athens, GA, USA
Emory Vaccine Center. Atlanta, GA, USA/Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Department of Pathology University of Utah Salt Lake City, UT, USA/Department of Pediatrics Emory University School of Medicine Atlanta, GA, USA/Division of Infectious Diseases Department of Medicine Emory University School of Medicine Atlanta, GA, USA/Yerkes/Emory National Primate Research Center Emory University Atlanta, GA, USA
Biotechnology Core Facility Branch. Centers for Disease Control and Prevention. Atlanta, GA, USA
University of Tennessee. Knoxville, TN, USA/Yerkes/Emory National Primate Research Center. Emory University. Atlanta, GA USA
Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine. Department of Medicine. Emory University School of Medicine. Atlanta, GA, USA
School of Chemical & Biomolecular Engineering. Georgia Institute of Technology. Atlanta, GA, USA
The Wallace H. Coulter Department of Biomedical Engineering. Georgia Institute of Technology and Emory University. Atlanta, GA, USA
Division of Infectious Diseases. Department of Medicine. Emory University. School of Medicine. Atlanta, GA, USA
Emory Vaccine Center, Yerkes/Emory National Primate Research Center. Emory University. Atlanta, GA, USA/Division of Infectious Diseases. Department of Medicine. Emory University School of Medicine. Atlanta, GA, USA/Institute of Bioinformatics. University of Georgia. Athens, USA/Center for Tropical and Emerging Global Diseases. University of Georgia. Athens. GA, USA/Department of Genetics. University of Georgia. Athens, GA, USA
Institute of Bioinformatics. University of Georgia, Athens, GA, USA
Department of Medicine. Vanderbilt University Medical Center. Nashville, TN, USA/ Institute of Bioinformatics. University of Georgia, Athens, GA, USA
Cancer Data Science Initiatives. Frederick National Laboratory for Cancer Research. Frederick, MD, USA/Institute of Bioinformatics. University of Georgia, Athens, GA, USA
Center for Tropical and Emerging Global Diseases. University of Georgia. Athens, GA, USA
Center for Tropical and Emerging Global Diseases. University of Georgia. Athens, GA, USA/Institute of Bioinformatics, University of Georgia. Athens, GA, USA
Department of Pediatrics. Emory University School of Medicine. Atlanta, GA, USA/Emory Vaccine Center. Yerkes/Emory National Primate Research Center. Emory University, Atlanta, GA, USA
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine. Department of Medicine. Emory University School of Medicine. Atlanta, GA, USA/Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil/Emory Vaccine Center. Yerkes. Atlanta, GA, USA/Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Present address: Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA/Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Senior Public Health Informaticist. MITRE Corp, Atlanta, GA, USA/ Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Department of Biomedical Engineering. University of Texas at Austin. Austin, TX, USA/Institute of Bioinformatics. University of Georgia. Athens, GA, USA
Institute of Bioinformatics, University of Georgia. Athens, GA, USA
Institute of Bioinformatics, University of Georgia, Athens, GA, USA
Interdisciplinary Disease Ecology Across Scales Research Traineeship Program. Institute of Bioinformatics. Center for the Ecology of Infectious Diseases. University of Georgia. Athens, GA, USA/Institute of Bioinformatics. University of Georgia. Athens, GA, USA
Center for Integrative Genomics. School of Biology. Georgia Institute of Technology. Atlanta, GA, USA
Department of Medicine. Brigham and Women’s Hospital. Harvard Medical School. Boston, MA, USA/School of Chemical & Biomolecular Engineering. Georgia Institute of Technology. Atlanta, GA, USA
The Wallace H. Coulter Department of Biomedical Engineering. Georgia Institute of Technology and Emory University. Atlanta, GA, USA
Federal Drug Administration. Silver Spring, MD, USA/Institute of Bioinformatics. University of Georgia. Athens.GA, USA
Complex Carbohydrate Research Center. Department of Biochemistry. University of Georgia. Athens, GA, USA
Complex Carbohydrate Research Center. Department of Biochemistry. University of Georgia, Athens. GA, USA
Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA
Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA
Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA
Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA/The Wallace H. Coulter Department of Biomedical Engineering. Georgia Institute of Technology and Emory University. Atlanta, GA, USA
Center for Tropical and Emerging Global Disease. University of Georgia. Athens, GA, USA/ Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Department of Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA, USA/ Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Department of Biology. Wake Forest University. Winston Salem, NC, USA/Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Institutional Animal Care and Use Committee, Research Compliance and Research Integrity Office, Emory University, Atlanta, GA, USA// Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Complex Carbohydrate Research Center. Department of Biochemistry. University of Georgia, Athens. GA, USA
Casma Therapeutics, Cambridge, MA, USA/Division of Endocrinology. Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA
Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. Lowance Center for Human Immunology. Emory University. Atlanta, GA, USA
Department of Pediatrics. Emory University School of Medicine. Atlanta, GA, USA
University of Texas at San Antonio. San Antonio, TX, USA/Institute of Bioinformatics. University of Georgia. Athens, GA, USA/Department of Mathematics, Institute of Bioinformatics, University of Georgia, Athens, GA, USA
Emory Vaccine Center. Atlanta, GA, USA/Emory National Primate Research Center. Emory University. Atlanta, GA, USA
Department of Pathology University of Utah Salt Lake City, UT, USA/Department of Pediatrics Emory University School of Medicine Atlanta, GA, USA/Division of Infectious Diseases Department of Medicine Emory University School of Medicine Atlanta, GA, USA/Yerkes/Emory National Primate Research Center Emory University Atlanta, GA, USA
Biotechnology Core Facility Branch. Centers for Disease Control and Prevention. Atlanta, GA, USA
University of Tennessee. Knoxville, TN, USA/Yerkes/Emory National Primate Research Center. Emory University. Atlanta, GA USA
Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine. Department of Medicine. Emory University School of Medicine. Atlanta, GA, USA
School of Chemical & Biomolecular Engineering. Georgia Institute of Technology. Atlanta, GA, USA
The Wallace H. Coulter Department of Biomedical Engineering. Georgia Institute of Technology and Emory University. Atlanta, GA, USA
Division of Infectious Diseases. Department of Medicine. Emory University. School of Medicine. Atlanta, GA, USA
Emory Vaccine Center, Yerkes/Emory National Primate Research Center. Emory University. Atlanta, GA, USA/Division of Infectious Diseases. Department of Medicine. Emory University School of Medicine. Atlanta, GA, USA/Institute of Bioinformatics. University of Georgia. Athens, USA/Center for Tropical and Emerging Global Diseases. University of Georgia. Athens. GA, USA/Department of Genetics. University of Georgia. Athens, GA, USA
Abstract
Plasmodium cynomolgi causes zoonotic malarial infections in Southeast Asia and this parasite species is important as a model for Plasmodium vivax and Plasmodium ovale. Each of these species produces hypnozoites in the liver, which can cause relapsing infections in the blood. Here we present methods and data generated from iterative longitudinal systems biology infection experiments designed and performed by the Malaria Host-Pathogen Interaction Center (MaHPIC) to delve deeper into the biology, pathogenesis, and immune responses of P. cynomolgi in the Macaca mulatta host. Infections were initiated by sporozoite inoculation. Blood and bone marrow samples were collected at defined timepoints for biological and computational experiments and integrative analyses revolving around primary illness, relapse illness, and subsequent disease and immune response patterns. Parasitological, clinical, haematological, immune response, and -omic datasets (transcriptomics, proteomics, metabolomics, and lipidomics) including metadata and computational results have been deposited in public repositories. The scope and depth of these datasets are unprecedented in studies of malaria, and they are projected to be a F.A.I.R., reliable data resource for decades.
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