Author | Barral Netto, Manoel | |
Author | Brodskyn, Claudia Ida | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Barral, Aldina Maria Prado | |
Access date | 2012-10-15T21:08:03Z | |
Available date | 2012-10-15T21:08:03Z | |
Document date | 1998 | |
Citation | BARRAL-NETTO, M. et al. Human_leishmaniasis/cytokines.bahia.br. Brazilian Journal of Medical Biological Research, v. 31, n. 1, p. 149-55, jan. 1998. | pt_BR |
ISSN | 0100-879X | |
URI | https://www.arca.fiocruz.br/handle/icict/5670 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Human_leishmaniasis/cytokines.bahia.br | pt_BR |
Type | Article | pt_BR |
Abstract | The cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-gamma is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced production of or synergize with IFN-gamma, and those cytokines that counterbalance its effects is fundamental for developing rational immunotherapeutic or immunoprophylactic approaches to leishmaniasis. Here we focus on the cytokine balance in human leishmaniasis, particularly IL-10 as an IFN-gamma opposing cytokine, and IL-12 as an IFN-gamma inducer. The effects of these cytokines were evaluated in terms of several parameters of the human immune response. IL-10 reduced lymphocyte proliferation, IFN-gamma production and cytotoxic activity of responsive human peripheral blood mononuclear cells. Neutralization of IL-10 led to partial restoration of lymphoproliferation, IFN-gamma production and cytotoxic activity in unresponsive visceral leishmaniasis patients. IL-12 also restored the responses of peripheral blood mononuclear cells from visceral leishmaniasis patients. The responses obtained with IL-12 are higher than those obtained with anti-IL-10, even when anti-IL-10 is combined with anti-IL-4. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Human leishmaniasis | pt_BR |
Subject | Immunoregulation | pt_BR |
Subject | IL-12 | pt_BR |
Subject | IL-10 | pt_BR |
DeCS | Citocinas/fisiologia | pt_BR |
DeCS | Leishmaniose/imunologia | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Interleucina-10 | pt_BR |
DeCS | Interleucina-12 | pt_BR |