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https://www.arca.fiocruz.br/handle/icict/56529
CCL-2 AND CXCL-8: POTENTIAL PROGNOSTIC BIOMARKERS OF ACUTE KIDNEY INJURY AFTER A BOTHROPS ATROX SNAKEBITE
Author
Neves, Juliana Costa Ferreira
Ibiapina, Hiochelson Najibe Santos
Magalhães-Gama, Fábio
Sachett, Jacqueline Almeida Gonçalves
Silva, Iran Mendonça
Coelho, Kerolaine Fonseca
Alves, Eliane Campos
Tarragô, Andréa Monteiro
Ferreira, Luiz Carlos de Lima
Malheiro, Adriana
Monteiro, Wuelton Marcelo
Costa, Allyson Guimarães
Ibiapina, Hiochelson Najibe Santos
Magalhães-Gama, Fábio
Sachett, Jacqueline Almeida Gonçalves
Silva, Iran Mendonça
Coelho, Kerolaine Fonseca
Alves, Eliane Campos
Tarragô, Andréa Monteiro
Ferreira, Luiz Carlos de Lima
Malheiro, Adriana
Monteiro, Wuelton Marcelo
Costa, Allyson Guimarães
Affilliation
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/Post-Graduate Program in Health Sciences. René Rachou Institute, Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil/Amazonas Estate. Alfredo da Matta Foundation. Department of Education and Research. Manaus, AM, Brazil.
Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/ Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil/Graduate Program in Sciences Applied to Hematology. Amazonas Estate University. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/ Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil/Graduate Program in Sciences Applied to Hematology. Amazonas Estate University. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil/Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/Graduate Program in Health Sciences. René Rachou Institute, Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil/Amazonas Estate. Alfredo da Matta Foundation. Department of Education and Research. Manaus, AM, Brazil/Post-Graduate Program in Sciences Applied to Hematology. Amazonas Estate University. Manaus, AM, Brazil/Nursing School of Manaus. Amazonas Federal University. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/Post-Graduate Program in Health Sciences. René Rachou Institute, Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil/Amazonas Estate. Alfredo da Matta Foundation. Department of Education and Research. Manaus, AM, Brazil.
Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/ Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil/Graduate Program in Sciences Applied to Hematology. Amazonas Estate University. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/ Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil/Graduate Program in Sciences Applied to Hematology. Amazonas Estate University. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil.
Post-graduate Program in Tropical Medicine. Amazonas State University. Manaus, AM, Brazil/Carlos Borborema Clinical Research Institute. Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil/Post-Graduate Program in Basic and Applied Immunology. Federal University of Amazonas. Manaus, AM, Brazil/Graduate Program in Health Sciences. René Rachou Institute, Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Directorate of Teaching and Research. Hematology and Hemotherapy Foundation of Amazonas. Manaus, AM, Brazil/Amazonas Estate. Alfredo da Matta Foundation. Department of Education and Research. Manaus, AM, Brazil/Post-Graduate Program in Sciences Applied to Hematology. Amazonas Estate University. Manaus, AM, Brazil/Nursing School of Manaus. Amazonas Federal University. Manaus, AM, Brazil.
Abstract
In the Brazilian Amazon, the snake Bothrops atrox is the primary cause of snakebites. B. atrox (BaV) venom can cause systemic pathophysiological changes such as acute kidney injury (AKI), which leads to the production of chemokines and cytokines in response to the envenomation. These soluble immunological molecules act by modulating the inflammatory response; however, the mechanisms associated with the development of AKI are still poorly understood. Here, we characterize the profile of these soluble immunological molecules as possible predictive biomarkers of the development of AKI. The study involved 34 patients who had been victims of snakebites by Bothrops sp. These were categorized into two groups according to the development of AKI (AKI(-)/AKI(+)), using healthy donors as the control (HD). Peripheral blood samples were collected at three-time points: before antivenom administration (T0) and at 24 and 48 hours after antivenom (T1 and T2, respectively). The soluble immunological molecules (CXCL-8, CCL-5, CXCL-9, CCL-2, CXCL-10, IL-6, TNF, IL-2, IL-10, IFN-γ, IL-4, and IL-17A) were quantified using cytometric bead array. Our results demonstrated an increase in CXCL-9, CXCL-10, IL-6, IL-2, IL-10, and IL-17A molecules in the groups of patients who suffered Bothrops snakebites (AKI(-) and AKI(+)) before antivenom administration, when compared to HD. In the AKI(+) group, levels of CXCL-8 and CCL-2 molecules were elevated on admission and progressively decreased during the clinical evolution of patients after antivenom administration. In addition, in the signature analysis, these were produced exclusively by the group AKI(+) at T0. Thus, these chemokines may be related to the initiation and extension of AKI after envenomation by Bothrops and present themselves as two potential biomarkers of AKI at T0.
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