Author | Conteville, Liliane Costa | |
Author | Vicente, Ana Carolina Paulo | |
Access date | 2023-01-05T19:48:57Z | |
Available date | 2023-01-05T19:48:57Z | |
Document date | 2022 | |
Citation | Conteville, Liliane Costa; VICENTE, Ana Carolina Paulo. A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits. Scientifc Reports, v. 12, 12102, p. 1 - 9, 2022. | en_US |
ISSN | 2045-2322 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/56340 | |
Language | eng | en_US |
Publisher | Nature Portfolio | en_US |
Rights | open access | |
Subject in Portuguese | Rede de plasmídeo | en_US |
Subject in Portuguese | Intestino microbioma | en_US |
Subject in Portuguese | Semi-isolados grupos humanos | en_US |
Subject in Portuguese | Características únicas | en_US |
Subject in Portuguese | Metabolismo e virulência compartilhados | en_US |
Title | A plasmid network from the gut microbiome of semi‑isolated human groups reveals unique and shared metabolic and virulence traits | en_US |
Type | Article | |
DOI | 10.1038/s41598-022-16392-z | |
Abstract | The plasmids in gut microbiomes have the potential to contribute to the microbiome community, as
well as human health and physiology. Nevertheless, this niche remains poorly explored. In general,
most microbiome studies focus on urban-industrialized groups, but here, we studied semi-isolated
groups from South America and Africa, which would represent a link between ancestral and modern
human groups. Based on open metagenomic data, we characterized the set of plasmids, including
their genes and functions, from the gut microbiome of the Hadza, Matses, Tunapuco, and Yanomami,
semi-isolated groups with a hunter, gather or subsistence lifestyle. Unique plasmid clusters and gene
functions for each human group were identified. Moreover, a dozen plasmid clusters circulating in
other niches worldwide are shared by these distinct groups. In addition, novel and unique plasmids
harboring resistance (encompassing six antibiotic classes and multiple metals) and virulence (as
type VI secretion systems) genes were identified. Functional analysis revealed pathways commonly
associated with urban-industrialized groups, such as lipopolysaccharide biosynthesis that was
characterized in the Hadza gut plasmids. These results demonstrate the richness of plasmids in semiisolated
human groups’ gut microbiome, which represents an important source of information with
biotechnological/pharmaceutical potential, but also on the spread of resistance/virulence genes to
semi-isolated groups. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Plasmid network | en_US |
Subject | Gut microbiome | en_US |
Subject | Semi‑isolated human groups | en_US |
Subject | Reveals unique and shared metabolic | en_US |
Subject | Virulence traits | en_US |