Author | Souza, Valderes Lemos de | |
Author | Souza, Juliana Ascenção | |
Author | Silva, Tânia Maria Correia | |
Author | Veras, Patrícia Sampaio Tavares | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Access date | 2012-10-02T21:28:31Z | |
Available date | 2012-10-02T21:28:31Z | |
Document date | 2000 | |
Citation | LEMOS de SOUZA, V. et al. Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice. Microbes and Infection, v. 2, n. 15, p. 1807-15, dec. 2000. | pt_BR |
ISSN | 1286-4579 | |
URI | https://www.arca.fiocruz.br/handle/icict/5627 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice. | pt_BR |
Type | Article | pt_BR |
Abstract | Most experimental studies on leishmaniasis compare two different inbred strains of
mice that are resistant or susceptible to one species of Leishmania. In the present study we
characterized some cytokines and nitric oxide production as well as histological changes related to
resistance and susceptibility in isogenic CBA mice infected with Leishmania major or Leishmania
amazonensis. CBA mice are capable of controlling infection with L. major, but they succumb to infection
with L. amazonensis. Cells from susceptible L. amazonensis-infected CBA mice produced interleukin
(IL)-4 and IL-10 but no interferon (IFN)-γ. On the other hand, resistant L. major-infected CBA mice
produced IFN-γ and IL-10, but IL-4 was detected only in the first week of infection. Histopathological
studies showed patterns of tissue responses at the site of the infection and in the draining lymph nodes
that correlated with resistance or susceptibility. Resistant mice showed a mixed inflammatory cell
infiltration and granulomas in the lesions, whereas in susceptible mice only heavily parasitized
macrophages were seen. Our results indicate an important role of the parasite species in determining the
pattern of immune response. L. amazonensis induces a Th2-type immune response, whereas L. major
induces a Th1-type response. These factors must be identified and taken into account in the strategies for
the development of vaccines against leishmaniasis. The model presented here will be useful for the study
of such factors. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | CBA | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Histopathology | pt_BR |
Subject | Immunology | pt_BR |
Subject | Leishmania amazonensis | pt_BR |
Subject | Leishmania major | pt_BR |
DeCS | Leishmania major/patogenicidade | pt_BR |
DeCS | Leishmania/patogenicidade | pt_BR |
DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
DeCS | Leishmaniose Cutânea/patologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Células Cultivadas | pt_BR |
DeCS | Citocinas/biossíntese | pt_BR |
DeCS | Leishmaniose Cutânea/parasitologia | pt_BR |
DeCS | Linfonodos/citologia | pt_BR |
DeCS | Linfonodos/imunologia | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Camundongos Endogâmicos CBA | pt_BR |
DeCS | Óxido Nítrico/biossíntese | pt_BR |
DeCS | Pele/patologia | pt_BR |