Author | Rangel, Leonardo da Silva | |
Author | Oliveira, Adriana Passos de | |
Author | Falcão, Deborah Quintanilha | |
Author | Santos, Marcelo Guerra | |
Author | Von Ranke, Natalia Lindimar | |
Author | Rodrigues, Carlos Rangel | |
Author | Santos, José Augusto Albuquerque dos | |
Author | Rocha, Leandro | |
Author | Faria, Robson Xavier | |
Access date | 2022-12-30T22:05:56Z | |
Available date | 2022-12-30T22:05:56Z | |
Document date | 2022 | |
Citation | RANGEL, Leonardo da Silva et al. Nanoemulsion of Sideroxylon obtusifolium as an Alternative to Combat Schistosomiasis. Frontiers in Plant Science, v. 13, Article 853002, p.1 - 10, May 2022. | en_US |
ISSN | 1664-462X | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/56229 | |
Language | eng | en_US |
Publisher | Frontiers Media | en_US |
Rights | open access | |
Subject in Portuguese | Nanoemulsão | en_US |
Subject in Portuguese | Moluscicidas | en_US |
Subject in Portuguese | Biomphalaria | en_US |
Subject in Portuguese | Sideroxylon obtusifolium | en_US |
Subject in Portuguese | Extrato vegetal | en_US |
Title | Nanoemulsion of Sideroxylon obtusifolium as an Alternative to Combat Schistosomiasis | en_US |
Type | Article | |
DOI | 10.3389/fpls.2022.853002 | |
Abstract | Schistosomiasis is caused by the intestinal parasite Schistosoma mansoni. Individuals
are affected by schistosomiasis when they are exposed to aquatic environments
contaminated with Schistosoma cercariae that emerged from the infected intermediate
host mollusk of the genus Biomphalaria. The WHO recommends using molluscicidal
products to reduce the snail population and disease transmission. The WHO
encourages the search for alternative substances in schistosomiasis control. Natural
products are seen as a promising alternative because they are abundant in countries
where schistosomiasis is endemic and have many different substances in their extracts,
impairing cases of resistance. Therefore, the nanoemulsion effect of a butanol-soluble
fraction of Sideroxylon obtusifolium leaves was evaluated against three study points in
the biological cycle of the disease, that is, adults and young Biomphalaria glabrata,
spawning by the host mollusk, and infectious larvae of the parasite. Extract-SOB
(butanol fraction) and nano-SOB (nanoemulsion) demonstrated promising activity in
adult B. glabrata population control with an LC50 of 125.4 mg/L, an LC90 of 178.1 mg/L,
an LC50 of 75.2 mg/L, and an LC90 of 97 mg/L. Nano-SOB presented greater potency
against young B. glabrata, with an LC90 of 72.1 mg/L and an LC50 of 58.3 mg/L. Still,
relevant activity against S. mansoni cercariae was eliminated in 4 h (LC90: 34.6 mg/L).
Nano-SOB reduced viable spawning by approximately 30% at 178.1 and 97 mg/L.
Referring to most substances in this extract, quercetin-3-rhamnosyl-(1-6)-galactoside
and hyperoside may cause low environmental toxicity and human toxicity according to
in silico analysis. Thus, nano-SOB is a promising agent to combat B. glabrata population
growth and schistosomiasis transmission. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Programa de Pós-Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal Fluminense. Laboratório de Tecnologia de Produtos Naturais. Niterói, RJ, Brasil. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Formação de Professores. Departamento de Ciências. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil | en_US |
Affilliation | Universidade Federal Fluminense. Laboratório de Tecnologia de Produtos Naturais. Niterói, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Programa de Pós-Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil. | en_US |
Subject | Nanoemulsion | en_US |
Subject | Molluscicides | en_US |
Subject | Biomphalaria | en_US |
Subject | Sideroxylon obtusifolium | en_US |
Subject | Plant extract | en_US |