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THE SARS‐COV‐2MU VARIANT SHOULD NOT BE LEFT ASIDE: IT WARRANTS ATTENTION FOR ITS IMMUNO‐ESCAPING ABILITY
SARS coronavírus
Bioestatística e Bioinformática
Genética
Classificação de vírus
Biostatistics & Bioinformatics
Genetics
SARS coronavirus
Virus classification
Author
Affilliation
Dipartimento di Scienze biochimiche “A. Rossi Fanelli”, Sapienza Università di Roma, Roma, Italy.
Dipartimento di Scienze biochimiche “A. Rossi Fanelli”, Sapienza Università di Roma, Roma, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Department of Science and Technology for Humans and the Environment, University of Campus Bio‐Medico di Roma, Rome, Italy / Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.
Department of Physical and Chemical Sciences, University of L'Aquila, L'Aquila, Italy.
Policlinico Agostino Gemelli, Roma, Italy.
Center of Genomics, Genetics and Biology, Siena, Italy.
Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
Dipartimento di Scienze biochimiche “A. Rossi Fanelli”, Sapienza Università di Roma, Roma, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Department of Science and Technology for Humans and the Environment, University of Campus Bio‐Medico di Roma, Rome, Italy / Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.
Department of Physical and Chemical Sciences, University of L'Aquila, L'Aquila, Italy.
Policlinico Agostino Gemelli, Roma, Italy.
Center of Genomics, Genetics and Biology, Siena, Italy.
Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
Abstract
The COVID‐19 pandemic continues to have a threatening impact on a global scale,
largely due to the emergence of newly SARS‐CoV‐2 variants. The Mu (PANGO
lineage B.1.621), was first identified in Colombia in January 2021 and was classified
as a variant of interest (VOI) in August 2021, due to a constellation of mutations that
likely‐mediate an unexpectedly enhanced immune resistance to inactivated vaccineelicited
antibodies. Despite recent studies suggesting that the Mu variant appears to
have less infectivity than the Delta variant, here we examined the structural effect of
the Mu spike protein mutations and predicted the potential impact on infectivity of
the Mu variant compared with the Delta and Delta plus spike protein.
Keywords in Portuguese
Variação antigênicaSARS coronavírus
Bioestatística e Bioinformática
Genética
Classificação de vírus
Keywords
Antigenic variationBiostatistics & Bioinformatics
Genetics
SARS coronavirus
Virus classification
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