Author | Silva, Gabriela Vivili Domingues | |
Author | Dolens, Eder da Silva | |
Author | Paranaíba, Lívia Máris Ribeiro | |
Author | Ayroza, Ana Lúcia Carrinho | |
Author | Rocha, Clarissa Araujo Gurgel | |
Author | Almangush, Alhadi | |
Author | Salo, Tuula | |
Author | Brennan, Peter A. | |
Author | Coletta, Ricardo D. | |
Access date | 2022-12-22T14:51:01Z | |
Available date | 2022-12-22T14:51:01Z | |
Document date | 2022 | |
Citation | SILVA, Gabriela Vivili Domingues et al. Exploring the combination of tumor-stroma ratio,tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis. Journal of Oral Pathology and Medicine, p. 1-8, 2022. | en_US |
ISSN | 1600-0714 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/56162 | |
Sponsorship | Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). | en_US |
Language | eng | en_US |
Publisher | Wiley | en_US |
Rights | open access | en_US |
Subject in Portuguese | Características histopatológicas | en_US |
Subject in Portuguese | Câncer bucal | en_US |
Subject in Portuguese | Brotamento tumoral | en_US |
Subject in Portuguese | Relação tumor-estroma | en_US |
Subject in Portuguese | Classificação da OMS | en_US |
Subject in Portuguese | Sistema | en_US |
Title | Exploring the combination of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early-stage oral squamous cell carcinoma prognosis | en_US |
Type | Article | en_US |
DOI | 10.1111/jop.13359 | |
Abstract | Background: While the relevance of the World Health Organization histopathological grading system as a prognostic tool for oral squamous cell carcinoma has received many critics, other histopathological features such as tumor-troma ratio, tumorinfiltrating lymphocytes, and tumor budding are displaying promising results. Here, we evaluated the prognostic impact of the incorporation of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding into World Health Organization histopathological grading for patients with oral squamous cell carcinoma. Methods: A total of 95 patients with early-stage oral squamous cell carcinoma were enrolled in the study, and World Health Organization tumor grading, tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding were evaluated in surgical slides stained with hematoxylin and eosin. Survival analyses for cancer-specific survival and disease-free survival were performed using Cox regression models, and receiver operating characteristic curves were applied for assessment of the performance of the combinations. Results: Tumor-stroma ratio (stroma-rich) was significantly and independently associated with both shortened cancer-specific survival and poor disease-free survival, individually and in combination with World Health Organization histopathological grading. The combination of tumor-stroma ratio with World Health Organization grading did not improve the discriminatory ability compared to tumor-stroma ratio alone. Although low tumor-infiltrating lymphocytes were associated with shortened cancer-specific survival, the association did not withstand multivariate analysis. However, in combination with World Health Organization grading, low tumor-infiltrating lymphocytes were independently associated with poor cancer-specific survival. The
combination of tumor-infiltrating lymphocytes and World Health Organization histopathological grading displayed a better discrimination of poor cancer-specific survival than tumor-infiltrating lymphocytes alone, but not at a significant level. Conclusion: Our findings support tumor-stroma ratio as a potential prognostic marker for patients with oral squamous cell carcinoma, and the incorporation of tumor-infiltrating lymphocytes into the World Health Organization grading system improves the prognostic ability of the tumor grading alone. | en_US |
Affilliation | Universidade Estadual de Campinas. Escola de Odontologia Departamento de Diagnóstico Bucal. Piracicaba, SP, Brasil. | en_US |
Affilliation | Universidade Estadual de Campinas. Escola de Odontologia. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil / Universidade de Western Paulista. Escola de Odontologia. Presidente Prudente, SP, Brasil. | en_US |
Affilliation | Federal Universidade de Alfenas. Instituto de Ciências Biomédicas. Departamento de Patologia e Parasitologia. Alfenas, MG, Brasil. | en_US |
Affilliation | Universidade Estadual Oeste do Paraná. Faculdade de Odontologia. Centro de Ciências Biológicas e do Saúde. Cascavel, PR, Brasil. | en_US |
Affilliation | Oswaldo Fundação Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Molecular Biologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Odontologia. Departamento de Propedêutica. Salvador, BA, Brasil. | en_US |
Affilliation | Department of Pathology. University of Turku. Turku, Finland / Department of Oral and Maxillofacial Diseases. University of Helsinki. Helsinki, Finland. | en_US |
Affilliation | Department of Oral and Maxillofacial Diseases. University of Helsinki. Helsinki, Finland / Cancer and Translational Medicine Research Unit. Medical Research Center Oulu. University of Oulu and Oulu University Hospital. Oulu, Finland. | en_US |
Affilliation | Department of Oral and Maxillofacial Surgery. Queen Alexandra Hospital. Portsmouth, UK. | en_US |
Affilliation | Universidade Estadual de Campinas. Escola de Odontologia Departamento de Diagnóstico Bucal. Piracicaba, SP, Brasil / Universidade Estadual de Campinas. Escola de Odontologia. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil. | en_US |
Subject | Histopathological features | en_US |
Subject | Oral cancer | en_US |
Subject | Tumor budding | en_US |
Subject | Tumor-stroma ratio | en_US |
Subject | WHO grading | en_US |
Subject | System | en_US |
DeCS | Neoplasias Bucais | en_US |