Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/56077
DIAGNOSTIC AND THERAPEUTIC BIOMARKERS IN COLORECTAL CANCER: A REVIEW
Author
Affilliation
Diagnosis and Therapy of Infectious Diseases and Cancer. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Diagnosis and Therapy of Infectious Diseases and Cancer. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Department of Biological Sciences. University of Medical Sciences Ondo. Ondo State, Nigeria.
Diagnosis and Therapy of Infectious Diseases and Cancer. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Department of Biological Sciences. University of Medical Sciences Ondo. Ondo State, Nigeria.
Diagnosis and Therapy of Infectious Diseases and Cancer. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Department of Infectious Diseases. College of Veterinary Medicine. University of Georgia Athens. Georgia, United States of America.
Diagnosis and Therapy of Infectious Diseases and Cancer. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Department of Biological Sciences. University of Medical Sciences Ondo. Ondo State, Nigeria.
Diagnosis and Therapy of Infectious Diseases and Cancer. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Department of Biological Sciences. University of Medical Sciences Ondo. Ondo State, Nigeria.
Diagnosis and Therapy of Infectious Diseases and Cancer. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Department of Infectious Diseases. College of Veterinary Medicine. University of Georgia Athens. Georgia, United States of America.
Abstract
Colorectal cancer (CRC) is a public health concern and the second most common type of cancer among men and women causing a significant mortality. Biomarkers closely linked to the disease morbidity could holds potential as diagnostic and/or prognostic biomarker for the disease. This review provides an overview of recent advances in the search for colorectal cancer biomarkers through genomics and proteomics according to clinical function and application. Specifically, a number of biomarkers were identified and discussed. Emphasis was placed on their clinical applications relative to the diagnosis and prognosis of CRC. The discovery of more sensitive and specific markers for CRC is an urgent need, and the study of molecular targets is extremely important in this process, as they will allow for a better understanding of colorectal carcinogenesis, identification and validation of potential genetic signatures.
Share