Author | Matos, Juliana Arruda de | |
Author | Gomes, Amanda da Silva | |
Author | Lima, Carla Ormundo G. Ximenes | |
Author | Schmaltz, Carolina Arana Stanis | |
Author | Oliveira, Cristiane Rocha de | |
Author | Silva, Grasiela Martins da | |
Author | Carijó, Júlia Herkenhoff | |
Author | Lopes, Marilena Aguiar | |
Author | Morais, Quenia Cristina Dias | |
Author | Brasil, Pedro Emmanuel Alvarenga Americano do | |
Access date | 2022-11-16T13:07:26Z | |
Available date | 2022-11-16T13:07:26Z | |
Document date | 2022 | |
Citation | MATOS, Juliana Arruda et al. Systematic Review on Efficacy of Preventive Measures for Surgical Site Infection by Multiple-Drug Resistant Gram-Negative Bacilli. The Brazilian Journal of Infectious Diseases, v. 26, n. 6, p. 1-8, 2022. | en_US |
ISSN | 1413-8670 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/55628 | |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | en_US |
Title | Systematic Review on Efficacy of Preventive Measures for Surgical Site Infection by Multiple-Drug Resistant Gram-Negative Bacilli | en_US |
Type | Article | en_US |
DOI | 10.1016/j.bjid.2022.102705 | |
Abstract | Background: There are no specific recommendations for prevention of surgical site infection (SSI) caused by multidrug resistant Gram-negative bacilli (MDR-GNB). Our objective was to systematically review the literature evaluating the efficacy and safety of measures specifically designed to prevent MDR-GNB SSI.
Methods: We searched MEDLINE, EMBASE, CINAHL and LILACS databases up to February 18, 2020. Randomized trials and observational cohort studies evaluating the efficacy of preventive measures against MDR-GNB SSI in adult surgical patients were eligible. We evaluated methodological quality of studies and general quality of evidence using Newcastle-Ottawa scale, Cochrane ROBINS-I and GRADE method. Random-effects meta-analyses were performed using Review Manager V.5.3 software.
Results: A total of 10,663 titles by searching databases were identified. Two retrospective observational studies, comparing surgical antibiotic prophylaxis (SAP) with or without aminoglycoside in renal transplantation recipients, and one non-randomized prospective study, evaluating ertapenem vs. cephalosporin plus metronidazole for SAP in extended spectrum beta-lactamase producing Enterobacteriales carriers undergoing colon surgery, were included. Risk of bias was high in all studies. Meta-analysis was performed for the renal transplantation studies, with 854 patients included. Combined relative risk (RR) for MDR GNB SSI was 0.57 (95%CI: 0.25-1.34), favoring SAP with aminoglycoside (GRADE: moderate).
Conclusions: There are no sufficient data supporting specific measures against MDR-GNB SSI. Prospective, randomized studies are necessary to assess the efficacy and safety of SAP with aminoglycoside for MDR-GNB SSI prevention among renal transplantation recipients and other populations | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Imunização e Vigilância em Saúde. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Imunização e Vigilância em Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Drug resistance, multiple | en_US |
Subject | Gram-negative bacterial infections | en_US |
Subject | Infection control | en_US |
Subject | Surgical wound infection | en_US |
Subject | Systematic review | en_US |