Author | Guga, Godfrey | |
Author | Elwood, Sarah | |
Author | Kimathi, Caroline | |
Author | Kang, Gagandeep | |
Author | Kosek, Margaret N. | |
Author | Lima, Aldo A. M. | |
Author | Bessong, Pascal O. | |
Author | Samie, Amidou | |
Author | Haque, Rashidul | |
Author | Leite, Jose Paulo | |
Author | Bodhidatta, Ladaporn | |
Author | Iqbal, Najeeha | |
Author | Page, Nicola | |
Author | Kiwelu, Ireen | |
Author | Bhutta, Zulfiqar A. | |
Author | Ahmed, Tahmeed | |
Author | Liu, Jie | |
Author | McQuade, Elizabeth T. Rogawski | |
Author | Houpt, Eric | |
Author | Platts-Mills, James A. | |
Author | Mduma, Estomih R. | |
Access date | 2022-11-10T17:14:26Z | |
Available date | 2022-11-10T17:14:26Z | |
Document date | 2022 | |
Citation | GUGA, Godfrey et al. Burden, Clinical Characteristics, Risk Factors, and Seasonality of Adenovirus 40/41 Diarrhea in Children in Eight Low-Resource Settings. Infectious Diseases Society of America. p. 1-8, May 2022. | en_US |
ISSN | 0020-2606 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/55578 | |
Language | eng | en_US |
Publisher | Oxford University Press | en_US |
Rights | open access | |
Subject in Portuguese | Adenovírus | en_US |
Subject in Portuguese | Crianças | en_US |
Subject in Portuguese | Diarréia | en_US |
Subject in Portuguese | qPCR | en_US |
Subject in Portuguese | Sazonalidade | en_US |
Title | Burden, Clinical Characteristics, Risk Factors, and Seasonality of Adenovirus 40/41 Diarrhea in Children in Eight Low-Resource Settings | en_US |
Type | Article | |
DOI | 10.1093/ofid/ofac241 | |
Abstract | Background. The application of molecular diagnostics has identified enteric group adenovirus serotypes 40 and 41 as important causes of diarrhea in children. However, many aspects of the epidemiology of adenovirus 40/41 diarrhea have not been described. Methods. We used data from the 8-site Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project birth cohort study to describe site- and age-specific incidence, risk factors, clinical characteristics, and seasonality.
Results. The incidence of adenovirus 40/41 diarrhea was substantially higher by quantitative polymerase chain reaction than enzyme immunoassay and peaked at 30 episodes per 100 child-years in children aged 7–15 months, with substantial variation in incidence between sites. A significant burden was also seen in children 0–6 months of age, higher than other viral etiologies with the exception of rotavirus. Children with adenovirus 40/41 diarrhea were more likely to have a fever than children with norovirus, sapovirus, and astrovirus (adjusted odds ratio [aOR], 1.62; 95% CI, 1.16–2.26) but less likely than children with rotavirus (aOR, 0.66; 95% CI, 0.49–0.91). Exclusive breastfeeding was strongly protective against adenovirus 40/41 diarrhea (hazard ratio, 0.64; 95% CI, 0.48–0.85), but no other risk factors were identified. The seasonality of adenovirus 40/41 diarrhea varied substantially between sites and did not have clear associations with seasonal variations in temperature or rainfall.
Conclusions. This study supports the situation of adenovirus 40/41 as a pathogen of substantial importance, especially in infants. Fever was a distinguishing characteristic in comparison to other nonrotavirus viral etiologies, and promotion of exclusive breastfeeding may reduce the high observed burden in the first 6 months of life. | en_US |
Affilliation | Haydom Global Health Research Centre, Haydom, Tanzania. | en_US |
Affilliation | Division of Infectious Diseases and International Health, University of Virginia. Charlottesville, Virginia, USA. | en_US |
Affilliation | Haydom Global Health Research Centre, Haydom, Tanzania. | en_US |
Affilliation | Christian Medical. College, Vellore, India. | en_US |
Affilliation | University of Virginia. Charlottesville. Division of Infectious Diseases and International Health. Virginia, USA / Asociación Benéfica PRISMA, Iquitos. Peru. | en_US |
Affilliation | Universidade Federal do Ceará. Fortaleza, CE, Brasil. | en_US |
Affilliation | University of Venda, Thohoyandou. South Africa. | en_US |
Affilliation | University of Venda, Thohoyandou. South Africa. | en_US |
Affilliation | International Centre for Diarrhoeal Disease Research. Bangladesh. Dhaka, Bangladesh. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Armed Forces Research Institute of Medical Sciences. Bangkok,Thailand. | en_US |
Affilliation | Aga Khan University. Karachi, Pakistan. | en_US |
Affilliation | National Institute for Communicable Diseases. Johannesburg, South Africa. | en_US |
Affilliation | Kilimanjaro Clinical Research Institute. Moshi, Tanzania. | en_US |
Affilliation | National Institute for Communicable Diseases. Johannesburg, South Africa. | en_US |
Affilliation | International Centre for Diarrhoeal Disease Research, Bangladesh. Dhaka, Bangladesh. | en_US |
Affilliation | Division of Infectious Diseases and International Health, University of Virginia. Charlottesville, Virginia, USA / School of Public Health, Qingdao University, Shandong, China. | en_US |
Affilliation | Rollins School of Public Health, Emory University. Atlanta, Georgia, USA. | en_US |
Affilliation | Division of Infectious Diseases and International Health, University of Virginia. Charlottesville, Virginia, USA . | en_US |
Affilliation | Division of Infectious Diseases and International Health, University of Virginia. Charlottesville, Virginia, USA . | en_US |
Affilliation | Haydom Global Health Research Centre, Haydom, Tanzania. | en_US |
Subject | Adenovirus | en_US |
Subject | Children | en_US |
Subject | Diarrhea | en_US |
Subject | qPCR | en_US |
Subject | Seasonality | en_US |