Author | Moll-Bernardes, Renata | |
Author | Fortier, Sérgio C. | |
Author | Sousa, Andréa S. | |
Author | Lopes, Renato D. | |
Author | Vera, Narendra | |
Author | Conde, Luciana | |
Author | Feldman, André | |
Author | Arruda, Guilherme | |
Author | Cabral-Castro, Mauro | |
Author | Albuquerque, Denílson C. | |
Author | Paula, Thiago C. | |
Author | Furquim, Thyago | |
Author | Loures, Vitor A. | |
Author | Giusti, Karla | |
Author | Oliveira, Nathália | |
Author | Macedo, Ariane | |
Author | Silva, Pedro Barros E. | |
Author | De Luca, Fábio | |
Author | Kotsugai, Marisol | |
Author | Domiciano, Rafael | |
Author | Silva, Flávia A. | |
Author | Santos, Mayara F. | |
Author | Souza, Olga F. | |
Author | Bozza, Fernando A. | |
Author | Luiz, Ronir R. | |
Author | Medei, Emiliano | |
Access date | 2022-11-07T19:20:33Z | |
Available date | 2022-11-07T19:20:33Z | |
Document date | 2022 | |
Citation | MOLL-BERNARDES, Renata et al. NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial. Journal of clinical medicine, v. 11, n. 13, p. 1-13, 2022 | en_US |
ISSN | 2077-0383 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/55520 | |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Title | NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial | en_US |
Type | Article | en_US |
DOI | 10.3390/jcm11133713 | |
Abstract | Cardiovascular comorbidities and immune-response dysregulation are associated with COVID-19 severity. We aimed to explore the key immune cell profile and understand its association with disease progression in 156 patients with hypertension that were hospitalized due to COVID-19. The primary outcome was progression to severe disease. The probability of progression to severe disease was estimated using a logistic regression model that included clinical variables and immune cell subsets associated with the primary outcome. Obesity; diabetes; oxygen saturation; lung involvement on computed tomography (CT) examination; the C-reactive protein concentration; total lymphocyte count; proportions of CD4+ and CD8+ T cells; CD4/CD8 ratio; CD8+ HLA-DR MFI; and CD8+ NKG2A MFI on admission were all associated with progression to severe COVID-19. This study demonstrated that increased CD8+ NKG2A MFI at hospital admission, in combination with some clinical variables, is associated with a high risk of COVID-19 progression in hypertensive patients. These findings reinforce the hypothesis of the functional exhaustion of T cells with the increased expression of NKG2A in patients with severe COVID-19, elucidating how severe acute respiratory syndrome coronavirus 2 infection may break down the innate antiviral immune response at an early stage of the disease, with future potential therapeutic implications. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D'Or São Luiz. Pathological Anatomy Laboratory. São Paulo, SP, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Duke University Medical Center. Duke Clinical Research Institute. Durham, NC, USA / Brazilian Clinical Research Institute. São Paulo, SP, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Institute of Biophysics Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Institute of Biophysics Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Anália Franco Hospital. São Paulo, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz São Caetano Hospital. São Caetano do Sul, SP, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Institute of Microbiology Paulo de Góes. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rio de Janeiro State University. Cardiology Department. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Jabaquara Hospital. São Paulo, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Sino Brasileiro Hospital. Osasco, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Anália Franco Hospital. São Paulo, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Villa Lobos Hospital. São Paulo, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Villa Lobos Hospital. São Paulo, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Jabaquara Hospital. São Paulo, SP, Brazil / Santa Casa of São Paulo. São Paulo, SP, Brazil. | en_US |
Affilliation | Brazilian Clinical Research Institute. São Paulo, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Morumbi Hospital. São Paulo, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Morumbi Hospital. São Paulo, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Anália Franco Hospital. São Paulo, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D'Or São Luiz. Pathological Anatomy Laboratory. São Paulo, SP, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Copa Star Hospital. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Public Health Studies Institute. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Biophysics Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. National Center for Structural Biology and Bioimaging. Rio de Janeiro, RJ, Brazil. | en_US |
Subject | COVID-19 | en_US |
Subject | HLA-DR | en_US |
Subject | NKG2A | en_US |
Subject | T cell | en_US |
Subject | Hypertension | en_US |
Subject | Immune response | en_US |