Author | Miranda, Rafaella Moraes de | |
Author | Fernandes, Rosilainy Surubi | |
Author | Fernandes, André Tavares da Silva | |
Author | Brito, Anielly Ferreira de | |
Author | Moreira, Silvia Bahadian | |
Author | Pereira, Renata Carvalho | |
Author | Mendes, Ygara da Silva | |
Author | Lima, Sheila Maria Barbosa de | |
Author | Pissinatti, Alcides | |
Author | Freire, Marcos da Silva | |
Author | Alencar, Jerônimo Augusto Fonseca | |
Author | Oliveira, Ricardo Lourenco de | |
Access date | 2022-10-23T18:33:30Z | |
Available date | 2022-10-23T18:33:30Z | |
Document date | 2022 | |
Citation | MIRANDA, Rafaella Moraes de et al. Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates. Viruses, v. 14, n. 10, p. 1-10, 11 Oct. 2022. | en_US |
ISSN | 1999-4915 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/55246 | |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | |
Subject in Portuguese | Primatas não humanos | pt_BR |
Subject in Portuguese | YF 17DD | pt_BR |
Subject in Portuguese | Competência vetorial | pt_BR |
Title | Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates | en_US |
Type | Article | |
DOI | 10.3390/v14102231 | |
Abstract | Beside humans, thousands of non-human primates (NHPs) died during the recent outbreak caused by the yellow fever virus (YFV) in Brazil. Vaccination of NHPs against YFV with the YF 17DD attenuated virus has emerged as a public health strategy, as it would reduce sylvatic transmission while also preserving endangered susceptible species. The hypothesis of establishing an uncontrolled transmission of this attenuated virus in nature was raised. We assessed vector competence of four sylvatic mosquito species, Haemagogus leucocelaenus, Haemagogus janthinomys/capricornii, Sabethes albiprivus, and Sabethes identicus, as well as the urban vector Aedes aegypti for YF 17DD attenuated vaccine virus when fed directly on eleven viremic lion tamarins or artificially challenged with the same virus. No infection was detected in 689 mosquitoes engorged on viremic lion tamarins whose viremia ranged from 1.05 × 10³ to 6.61 × 10³ FFU/mL, nor in those artificially taking ≤ 1 × 10³ PFU/mL. Low viremia presented by YF 17DD-vaccinated New World NHPs combined with the low capacity and null dissemination ability in sylvatic and domestic mosquitoes of this attenuated virus suggest no risk of its transmission in nature. Thus, vaccination of captive and free-living NHPs against YFV is a safe public health strategy. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Estadual do Ambiente. Centro de Primatologia do Rio de Janeiro. Guapimirim, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Estadual do Ambiente. Centro de Primatologia do Rio de Janeiro. Guapimirim, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Non-human primates | en_US |
Subject | YF 17DD | en_US |
Subject | Vector competence | en_US |
e-ISSN | 1999-4915 | |