Author | Tavares, Luciana P. | |
Author | Brüggemann, Thayse R. | |
Author | Rezende, Rafael M. | |
Author | Machado, Marina G. | |
Author | Cagnina, R. Elaine | |
Author | Shay, Ashley E. | |
Author | Garcia, Cristiana | |
Author | Nijmeh, Julie | |
Author | Teixeira, Mauro M. | |
Author | Levy, Bruce D. | |
Access date | 2022-10-10T11:34:32Z | |
Available date | 2022-10-10T11:34:32Z | |
Document date | 2022 | |
Citation | TAVARES, Luciana P. et al. Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection. American Society for Microbiology, v.13, n. 4, p. 1 - 16, July/August 2022. | en_US |
ISSN | 2150-7511 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/55058 | |
Language | eng | en_US |
Publisher | American Society for Microbiology | en_US |
Rights | open access | |
Subject in Portuguese | Vírus da gripe A | en_US |
Subject in Portuguese | Streptococcus pneumoniae | en_US |
Subject in Portuguese | Resolução da inflamação | en_US |
Subject in Portuguese | Mediadores pró-resolução | en_US |
Subject in Portuguese | Conjugados de maresina na regeneração de tecidos (MCTRs) | en_US |
Subject in Portuguese | Macrófagos alveolares | en_US |
Subject in Portuguese | Infecção secundária | en_US |
Title | Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection | en_US |
Type | Article | |
Abstract | Influenza A virus (IAV) infections are a leading cause of mortality worldwide.
Excess mortality during IAV epidemics and pandemics is attributable to secondary bacterial
infections, particularly pneumonia caused by Streptococcus pneumoniae. Resident alveolar
macrophages (rAMs) are early responders to respiratory infections that coordinate initial
host defense responses. Maresin conjugates in tissue regeneration (MCTRs) are recently elucidated
cysteinyl maresins that are produced by and act on macrophages. Roles for MCTRs
in responses to respiratory infections remain to be determined. Here, IAV infection led to
transient decreases in rAM numbers. Repopulated lung macrophages displayed transcriptional
alterations 21 days post-IAV with prolonged susceptibility to secondary pneumococcal
infection. Administration of a mix of MCTR1 to 3 or MCTR3 alone post-IAV decreased
lung inflammation and bacterial load 48 and 72 h after secondary pneumococcal infection.
MCTR-exposed rAMs had increased migration and phagocytosis of Streptococcus pneumoniae,
reduced secretion of CXCL1, and a reversion toward baseline levels of several IAVinduced
pneumonia susceptibility genes. Together, MCTRs counter regulated post-IAV
changes in rAMs to promote a rapid return of bacteria host defense.
IMPORTANCE Secondary bacterial pneumonia is a serious and common complication of
IAV infection, leading to excess morbidity and mortality. New host-directed approaches
are needed to complement antibiotics to better address this important global infectious
disease. Here, we show that harnessing endogenous resolution mechanisms for inflammation
by exogenous administration of a family of specialized proresolving mediators
(i.e., cys-MCTRs) increased macrophage resilience mechanisms after IAV to protect
against secondary infection from Streptococcus pneumoniae. | en_US |
Affilliation | Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA / Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas,. Laboratório de Imunofarmacologia,. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. | en_US |
Affilliation | Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas,. Laboratório de Imunofarmacologia,. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA | en_US |
Affilliation | Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas,. Laboratório de Imunofarmacologia,. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas,. Laboratório de Imunofarmacologia,. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. | en_US |
Subject | Influenza A virus | en_US |
Subject | Streptococcus pneumoniae | en_US |
Subject | Resolution of inflammation | en_US |
Subject | Proresolving mediators | en_US |
Subject | Maresin conjugates in tissue regeneration (MCTRs), | en_US |
Subject | Alveolar macrophages | en_US |
Subject | Secondary infection | en_US |