Author | Carvalho, João Marcos da Silva | |
Author | Campos, Eugênia Maria Teixeira de Araújo | |
Author | Ferreira, José Luiz Nunes | |
Author | Carvalho, Huliana Mourão | |
Author | Carneiro Neto, José Abraão | |
Author | Carneiro, Tássila de Oliveira | |
Author | Carvalho, Edgar Marcelino | |
Access date | 2022-09-20T14:16:14Z | |
Available date | 2022-09-20T14:16:14Z | |
Document date | 2022 | |
Citation | CARVALHO, João Marcos da Silva et al. Radiographic aspects in individuals infected by human T-lymphotropic virus type 1 (HTLV-1) with joint pain. Advances in Rheumatology, v. 62, n. 31, p. 1-7, 2022. | en_US |
ISSN | 2523-3106 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/54817 | |
Sponsorship | Fundação Maria Emília Pedreira Freire de Carvalho.
Conselho Nacional de Pesquisa (CNPq).
Ministério da Ciência, Tecnologia e Inovação.
Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). | en_US |
Language | eng | en_US |
Publisher | BMC | en_US |
Rights | open access | en_US |
MeSH | Human T-lymphotropic virus 1 | en_US |
MeSH | Arthralgia | en_US |
Subject in Portuguese | HTLV-1 | en_US |
Subject in Portuguese | Artropatia associada ao HTLV-1 | en_US |
Subject in Portuguese | Artralgia | en_US |
Subject in Portuguese | Aspectos radiográficos | en_US |
Title | Radiographic aspects in individuals infected by human T-lymphotropic virus type 1 (HTLV-1) with joint pain | en_US |
Type | Article | en_US |
DOI | 10.1186/s42358-022-00259-y | |
Abstract | Background: Joint pain in the absence or with little synovitis is observed in a large percentage of HTLV-1 infected subjects. As the virus infect CD4+and CD8+positive, macrophages and B cells an exaggerated production of pro infammatory cytokines is detected in these patients. However, the possible association of HTLV-1 infection with auto immune diseases has not been documented defnitively and the clinical characteristics of HTLV-1 associated arthropa thy has not been defned. The objective this study is to describe clinic and radiographic features in HTLV-1-infected individuals with complaints of joint pain. Methods: Cross-sectional study enrolling HTLV-1-infected individuals with chronic joint pain, aged up to 75 years, both genders and seronegative controls with osteoarthritis. All participants underwent conventional radiography of the hips, knees and ankles. Results: Eighty-one HTLV-1 infected patients and 30 subjects with osteoarthritis participated in the study. Polyarticu lar and symmetrical arthritis prevailed in the HTLV-1 positive group (54%), while oligoarticular and asymmetrical (44%) were more common in controls (p<0.05). The frequency of enthesophytes (90%) in HTLV-1-infected patients was greater than in the control group (73%) (p<0.05). Radiographic features were similar in HTLV-1 carriers and in patients with probable or defnite HTLV-1 associated myelopathy. The presence of enthesophytes in the absence of joint space reduction or osteophytes was only observed in HTLV-1-infected individuals (p<0.001). Magnetic resonance imaging of the ankles of fve HTLV-1-infected patients and fve controls demonstrated a higher frequency of enthesitis, bursitis and osteitis in the HTLV-1 infected group. Conclusion: HTLV-1-associated arthropathy is clinically characterized by symmetrical polyarthralgia and the main
radiological fnding is the presence of enthesophytes in the absence of osteophytes and joint space narrowing. | en_US |
Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Serviço de Imunologia do HUPES. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Divisão de Imunologia. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Serviço de Imunologia do HUPES. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Divisão de Imunologia. Salvador, BA, Brasil. | en_US |
Affilliation | Colégio Brasileiro de Radiologia E Diagnóstico por Imagem. Clínica de Diagnóstico por Imagem. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Serviço de Imunologia do HUPES. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Divisão de Imunologia. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Serviço de Imunologia do HUPES. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Divisão de Imunologia. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Serviço de Imunologia do HUPES. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Divisão de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | en_US |
Subject | HTLV-1 | en_US |
Subject | HTLV-1-associated arthropathy | en_US |
Subject | Arthralgia | en_US |
Subject | Radiographic aspects | en_US |
DeCS | Anticorpos Anti-HIV | en_US |
DeCS | Artralgia | en_US |