Author | Bezerra, Flávia Fioruci | |
Author | Normando, Paula | |
Author | Fonseca, Ana Carolina P. | |
Author | Zembrzuski, Verônica | |
Author | Campos Junior, Mario | |
Author | Cabello-Acero, Pedro Hernan | |
Author | Faerstein, Eduardo | |
Access date | 2022-08-15T11:36:03Z | |
Available date | 2022-08-15T11:36:03Z | |
Document date | 2022 | |
Citation | BEZERRA, Flávia Fioruci et al. Genetic, sociodemographic and lifestyle factors associated with serum 25-hydroxyvitamin D concentrations in Brazilian adults: the Pró-Saúde Study. Cadernos de Saúde Pública, Rio de Janeiro, v. 38, n. 1, e00287820, 2022. | pt_BR |
ISSN | 0102-311X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/54637 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Vitamina D | pt_BR |
Subject in Portuguese | Polimorfismo de nucleotídeo único | pt_BR |
Subject in Portuguese | Gordura Visceral | pt_BR |
Subject in Portuguese | Pigmentação da pele | pt_BR |
Title | Genetic, sociodemographic and lifestyle factors associated with serum 25-hydroxyvitamin D concentrations in Brazilian adults: the Pró-Saúde Study | pt_BR |
Alternative title | Fatores genéticos, sociodemográficos e de estilo de vida nas concentrações séricas de 25-hidroxivitamina D em adultos brasileiros: o Estudo Pró-Saúde | pt_BR |
Alternative title | Factores genéticos, sociodemográficos y estilo de vida asociados con la concentración sérica 25-hidroxivitamina D en adultos brasileños: Estudio Pro-Salud | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0102-311X00287820 | |
Abstract | This study aims to investigate factors associated with serum 25-hydroxyvitamin D [25(OH)D] concentration in Brazilian adults considering sociodemographic and lifestyle factors, as well as vitamin D-related single nucleotide polymorphisms (SNPs). This is a cross-sectional study (n = 491; 34-79y; 251 women), nested within a prospective cohort (Pró-Saúde Study). Associations between serum 25(OH)D and sociodemographic characteristics, diet, use of supplement, physical activity, season of blood collection, body fat, skin type, sun exposure index, and SNPs CYP2R1-rs10741657 and GC-rs2282679 were explored by multiple linear regression. The prevalence of serum 25(OH)D < 50nmol/L was 55%. Serum 25(OH)D was lower among women
(β = -4.38; 95%CI: -8.02; -0.74), those with higher visceral fat (β = -4.02; 95%CI: -5.92; -2.12), and those with AC and CC genotypes for GC-rs2282679 (β = -6.84; 95%CI: -10.09; -3.59; β = -10.63; 95%CI: -17.52; -3.74, respectively). Factors directly associated with serum 25(OH)D included summer
(β = 20.14; 95%CI: 14.38; 25.90), intermediate skin type (β = 6.16; 95%CI: 2.52; 9.80), higher sun exposure (β = 0.49; 95%CI: 0.22; 0.75), vitamin D intake (β = 0.48; 95%CI: 0.03; 0.93), and physical activity (β = 4.65; 95%CI: 1.54; 7.76). Besides physical activity, diet, and sun exposure, non-modifiable factors, such as GC genotypes must be considered when evaluating vitamin D insufficiency in mixed-race populations. Moreover, high visceral fat in association with poorer vitamin D status deserve attention given that both conditions are unfavorably related with chronic and acute health outcomes. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Nutrição. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Nutrição. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Vitamin D | pt_BR |
Subject | Single Nucleotide Polymorphism | pt_BR |
Subject | Visceral Fat | pt_BR |
Subject | Skin Pigmentation | pt_BR |