Author | Oliveira, Jéssica Araujo da Paixão de | |
Author | Athaide, Mariana Martins de | |
Author | Rahman, Atta Ur | |
Author | Barbosa, Mayara Garcia de Mattos | |
Author | Jardim, Marcia Maria | |
Author | Moraes, Milton Ozório | |
Author | Pinheiro, Roberta Olmo | |
Access date | 2022-08-11T14:17:11Z | |
Available date | 2022-08-11T14:17:11Z | |
Document date | 2022 | |
Citation | OLIVEIRA, Jéssica Araujo da Paixão de; et al. Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19. Frontiers in Cellular and Infection Microbiology, v. 12, Article 15738, p. 1 - 16, Feb. 2022. | pt_BR |
ISSN | 2235-2988 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/54594 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Via das quinureninas | pt_BR |
Subject in Portuguese | Neuropatia periférica | pt_BR |
Subject in Portuguese | Hanseníase | pt_BR |
Subject in Portuguese | COVID-19 | pt_BR |
Subject in Portuguese | Triptofano | pt_BR |
Title | Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19 | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fcimb.2022.815738 | |
Abstract | Inflammatory disorders are associated with the activation of tryptophan (TRYP) catabolism
via the kynurenine pathway (KP). Several reports have demonstrated the role of KP in the
immunopathophysiology of both leprosy and coronavirus disease 19 (COVID-19). The
nervous system can be affected in infections caused by both Mycobacterium leprae and
SARS-CoV-2, but the mechanisms involved in the peripheral neural damage induced by
these infectious agents are not fully understood. In recent years KP has received greater
attention due the importance of kynurenine metabolites in infectious diseases, immune
dysfunction and nervous system disorders. In this review, we discuss how modulation of
the KP may aid in controlling the damage to peripheral nerves and the effects of KP
activation on neural damage during leprosy or COVID-19 individually and we speculate its
role during co-infection. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Department of Surgery, University of Michigan. Ann Arbor, MI, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro,; Departamento de Neurologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Kynurenine pathway | pt_BR |
Subject | Peripheral neuropathy | pt_BR |
Subject | Leprosy | pt_BR |
Subject | COVID-19 | pt_BR |
Subject | Tryptophan | pt_BR |