Author | Furtado, Nathália Dias | |
Author | Raphael, Lidiane de Menezes | |
Author | Ribeiro, Ieda Pereira | |
Author | Melo, Iasmim Silva de | |
Author | Fernandes, Déberli Ruiz | |
Author | Gômez, Mariela Martínez | |
Author | Santos, Alexandre Araújo Cunha dos | |
Author | Nogueira, Mônica da Silva | |
Author | Castro, Márcia Gonçalves de | |
Author | Abreu, Filipe Vieira Santos de | |
Author | Martins, Lívia Carício | |
Author | Vasconcelos, Pedro Fernando da Costa | |
Author | Oliveira, Ricardo Lourenço de | |
Author | Bonaldo, Myrna Cristina | |
Access date | 2022-08-08T13:56:39Z | |
Available date | 2022-08-08T13:56:39Z | |
Document date | 2022 | |
Citation | FURTADO, Nathália Dias et al. Biological Characterization of Yellow Fever Viruses Isolated From Non-human Primates in Brazil With Distinct Genomic Landscapes. Frontiers in Microbiology, v. 13, Article 757084, p. 1-14, Feb. 2022. | pt_BR |
ISSN | 1664-302X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/54485 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Vírus da febre amarela | pt_BR |
Subject in Portuguese | Surtos no Brasil | pt_BR |
Subject in Portuguese | Marcadores genéticos | pt_BR |
Subject in Portuguese | Virulência | pt_BR |
Subject in Portuguese | Neurovirulência do camundongo | pt_BR |
Subject in Portuguese | Infecção celular | pt_BR |
Subject in Portuguese | Inibição viral mediada por interferon | pt_BR |
Title | Biological Characterization of Yellow Fever Viruses Isolated From Non-human Primates in Brazil With Distinct Genomic Landscapes | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fmicb.2022.757084 | |
Abstract | Since the beginning of the XXI Century, the yellow fever virus (YFV) has been cyclically spreading from the Amazon basin to Brazil’s South and Southeast regions, culminating in an unprecedented outbreak that started in 2016. In this work, we studied four YFV isolated from non-human primates obtained during outbreaks in the states of Rio Grande do Sul in 2008 (PR4408), Goiás (GO05), and Espírito Santo (ES-504) in 2017, and Rio de Janeiro (RJ 155) in 2019. These isolates have genomic differences mainly distributed in non-structural proteins. We compared the isolates’ rates of infection in mammal and mosquito cells and neurovirulence in adult mice. RJ 155 and PR4408 YFV isolates exhibited higher infectivity in mammalian cells and neurovirulence in mice. In mosquito Aag2 cells, GO05 and PR4408 displayed the lowest proliferation rates. These results suggest that RJ 155 and PR4408 YFV isolates carry some genomic markers that increase infectivity in mammal hosts. From this characterization, it is possible to contribute to discovering new molecular markers for the virulence of YFV. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto de Investigaciones Biológicas Clemente Estable. Montevideo, Uruguay. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Experimentação Animal. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. PA, Brasil. | pt_BR |
Affilliation | Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. PA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Yellow fever virus | pt_BR |
Subject | Brazil outbreaks | pt_BR |
Subject | Genetic markers | pt_BR |
Subject | Virulence | pt_BR |
Subject | Mouse neurovirulence | pt_BR |
Subject | Cell infection | pt_BR |
Subject | Interferon-mediated viral inhibition | pt_BR |