Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/541
Title: V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F.
Authors: Morgado, Mariza Gonçalves
Sabino, Ester C.
Shpaer, Eugene G.
Bongertz, Vera
Brigido, Luis F.
Guimaraes, Mark Drew Crosland
Castilho, Euclides Ayres de
Castro Filho, Bernardo Galvão
Mullins, James I.
Hendry, R. Michael
Mayer, Allen
Affilliation: Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. Rio de Janeiro, RJ, Brazil.
Instituto Adolfo Lutz. São Paulo, SP, Brazil.
Stanford University. School of Medicine. Department of Microbiology and Immunology. Stanford, CA, USA.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. Rio de Janeiro, RJ, Brazil.
Instituto Adolfo Lutz. São Paulo, SP, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Centre of Information for Health. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Centre of Information for Health. Rio de Janeiro, RJ, Brazil.
Laboratorio Avançado de Saude Publica, Centro de Pesquisa Gonçalo Moniz, FIOCRUZ, Bahia, Brazil.
Yiral and Rickettsial Disease Laboratory, California Department of Health Services. Berkeley, California
Abstract: Viral DNA sequences were determined over the V3 region of env from 28 infected individuals living in the high mV·l prevalence Brazilian cities of Rio de Janeiro and São Paulo. Twenty-six belonged to envelope sequence subtype B, prevalent in North America and Europe, and one was c1assifiedas subtype F, found recently in Brazil and in Romania (one appeared to be a B/F recombinant). Octameric sequences at the tip of the subtype B V3 loops were variable and distinct from those prevalent in North America and Europe. The GPGR motü, prevalent in North AmericanlEuropean strains, was found in only 8 (28.5%) sequences, whereas GWGR was found in 12 (43%) and novel sequences in 8 (28.5%). Brazilian subtype B sequences also diverged from the consensus North AmericanlEuropean strains over the remainder of the V3loop. These results suggest that Brazilian mv·l B strains may have important antigenic differences from prototype subtype B strains currently being evaluated for use in HIV vaccines. These results should be taken into account for future vaccine programs in Brazil.
Issue Date: 1994
Publisher: Mary Ann Liebert, Inc., Publishers
Citation: MORGADO, Mariza G. et al. V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F. AIDS research and human retroviruses, v.10, n.5, 1994.
ISSN: 0889-2229
Copyright: open access
Appears in Collections:ICICT - Artigos de Periódicos

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