Author | Monte Neto, Rubens Lima do | |
Author | Fernandez-Prada, Christopher | |
Author | Moretti, Nilmar Silvio | |
Access date | 2022-07-26T12:23:56Z | |
Available date | 2022-07-26T12:23:56Z | |
Document date | 2022 | |
Citation | MONTE NETO, Rubens Lima do; FERNANDEZ-PRADA, Christopher; MORETTI, Nilmar S. Sex under pressure: stress facilitates Leishmania in vitro hybridization. Trends in Parasitology, v. 38, n. 4, p. 274-276, 2022. doi: 10.1016/j.pt.2022.02.001 | pt_BR |
ISSN | 1471-4922 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/53965 | |
Language | eng | pt_BR |
Publisher | Elsevier Science | pt_BR |
Rights | restricted access | pt_BR |
Title | Sex under pressure: stress facilitates Leishmania in vitro hybridization | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.pt.2022.02.001 | |
Abstract | The selection of Leishmania hybrids in axenic culture was considered rare until recently, when Louradour and Ferreira et al., demonstrated that induced DNA damage facilitates genetic exchange, resulting in full genome tetraploid progenies in vitro. Meiosis-related gene homologues HAP2, GEX1, and RAD51 were found to be involved, opening new avenues for functional genomic studies. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Biotecnologia Aplicada ao Estudo de Patógenos. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Faculté de Médecine Vétérinaire. Département de Pathologie et Microbiologie. Université de Montréal. Saint-Hyacinthe, Québec, Canada. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Biologia Molecular de Patógenos. São Paulo, SP, Brasil. | pt_BR |
Subject | Leishmania | pt_BR |
Subject | genetic exchange | pt_BR |
Subject | hybrids | pt_BR |
Subject | in vitro | pt_BR |
Subject | sexual reproduction | pt_BR |
Subject | v | pt_BR |