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https://www.arca.fiocruz.br/handle/icict/53643
AN APPRAISAL ON THE DEGRADATION OF PARACETAMOL BY TIO2/UV SYSTEM IN AQUEOUS MEDIUM. PRODUCT IDENTIFICATION BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY (GC-MS)
Affilliation
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil
Abstract
The advanced oxidation of paracetamol (1) promoted by TiO2/UV system in aqueous medium was investigated. Continuous monitoring by several techniques, such as UV-Vis spectroscopy, HPLC (high performance liquid chromatography), TOC (total organic carbon), and ESI-MS (electrospray ionization mass spectrometry), revealed that whereas the removal of paracetamol was highly efficient under these conditions, its mineralization was not likewise accomplished. GC-MS (gas chromatography-mass spectrometry) analysis showed that hydroquinone, aliphatic carboxylic acids, monohydroxy and dihydroxy paracetamol were the main products formed as a result of such degradation process. Based on these results, a reaction route for the degradation of paracetamol induced by the TiO2/UV system was suggested. Fragmentation pathways, as obtained from the mass spectra data, were also proposed for the trimethylsilyl (TMS) derivatives of monohydroxy and dihydroxy paracetamol
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