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https://www.arca.fiocruz.br/handle/icict/53379
SCREENING FOR SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 IN CLOSE CONTACTS OF INDIVIDUALS WITH CONFIRMED INFECTION: PERFORMANCE AND OPERATIONAL CONSIDERATIONS
Rondônia
Allplex SARS-CoV-2 assay
SalivaDirect
Teste PADRÃO Q COVID-19 Ag
LumiraDx SARS-CoV-2 Ag test
Rondônia
Allplex SARS-CoV-2 assay
SalivaDirect
SD Biosensor STANDARD Q COVID-19 Ag
LumiraDx SARS-CoV-2 Ag test
Rondônia
Ensayo Allplex SARS-CoV-2
SalivaDirect
SD Biosensor STANDARD Q COVID-19 Ag
La Prueba LumiraDx SARS-CoV-2 Ag
COVID-19
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Kit de Reagentes para Diagnóstico
Author
Zobrist, Stephanie
Oliveira-Silva, Michelle
Vieira, Alexia Martines
Bansil, Pooja
Gerth-Guyette, Emily
Leader, Brandon T.
Golden, Allison
Slater, Hannah
Cruz, Catherine Duran de Lucena
Garbin, Eduardo
Sagalovsky, Mariana
Pal, Sampa
Gupta, Vin
Wolansky, Leo
Dall'Acqua, Deusilene Souza Vieira
Naveca, Felipe Gomes
Nascimento, Valdinete Alves do
Villalobos Salcedo, Juan Miguel
Drain, Paul K.
Costa, Alexandre Dias Tavares
Domingo, Gonzalo J.
Pereira, Dhélio
Oliveira-Silva, Michelle
Vieira, Alexia Martines
Bansil, Pooja
Gerth-Guyette, Emily
Leader, Brandon T.
Golden, Allison
Slater, Hannah
Cruz, Catherine Duran de Lucena
Garbin, Eduardo
Sagalovsky, Mariana
Pal, Sampa
Gupta, Vin
Wolansky, Leo
Dall'Acqua, Deusilene Souza Vieira
Naveca, Felipe Gomes
Nascimento, Valdinete Alves do
Villalobos Salcedo, Juan Miguel
Drain, Paul K.
Costa, Alexandre Dias Tavares
Domingo, Gonzalo J.
Pereira, Dhélio
Affilliation
Diagnostics - PATH. Seattle, WA, USA.
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.
Diagnostics - PATH. Seattle, WA, USA.
Diagnostics - PATH. Seattle, WA, USA.
Diagnostics - PATH. Seattle, WA, USA.
Diagnostics - PATH. Seattle, WA, USA.
Diagnostics - PATH. Seattle, WA, USA.
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.
Diagnostics - PATH. Seattle, WA, USA.
Diagnostics - PATH. Seattle, WA, USA.
Amazon.com. Seattle, WA, USA.
The Rockefeller Foundation. Pandemic Prevention Institute. New York, NY, USA.
Fundação Oswaldo Cruz. Fiocruz Rondônia. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Fiocruz Rondônia. Porto Velho, RO, Brasil.
University of Washington. Departments of Global Health and Medicine. Seattle, WA, USA.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Diagnostics - PATH. Seattle, WA, USA.
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.
Diagnostics - PATH. Seattle, WA, USA.
Diagnostics - PATH. Seattle, WA, USA.
Diagnostics - PATH. Seattle, WA, USA.
Diagnostics - PATH. Seattle, WA, USA.
Diagnostics - PATH. Seattle, WA, USA.
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.
Diagnostics - PATH. Seattle, WA, USA.
Diagnostics - PATH. Seattle, WA, USA.
Amazon.com. Seattle, WA, USA.
The Rockefeller Foundation. Pandemic Prevention Institute. New York, NY, USA.
Fundação Oswaldo Cruz. Fiocruz Rondônia. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Fiocruz Rondônia. Porto Velho, RO, Brasil.
University of Washington. Departments of Global Health and Medicine. Seattle, WA, USA.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Diagnostics - PATH. Seattle, WA, USA.
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.
Abstract
Background. Point-of-care and decentralized testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to inform public health responses. Performance evaluations in priority use cases such as contact tracing can highlight trade-offs in test selection and testing strategies. Methods. A prospective diagnostic accuracy study was conducted among close contacts of coronavirus disease 2019 (COVID19) cases in Brazil. Two anterior nares swabs (ANS), a nasopharyngeal swab (NPS), and saliva were collected at all visits. Vaccination history and symptoms were assessed. Household contacts were followed longitudinally. Three rapid antigen tests and 1 molecular method were evaluated for usability and performance against reference reverse-transcription polymerase chain reaction (RT-PCR) on nasopharyngeal swab specimens. Results. Fifty index cases and 214 contacts (64 household) were enrolled. Sixty-five contacts were RT-PCR positive during ≥1 visit. Vaccination did not influence viral load. Gamma variants were most prevalent; Delta variants emerged increasingly during implementation. The overall sensitivity of evaluated tests ranged from 33% to 76%. Performance was higher among symptomatic cases and those with cycle threshold (Ct) values ,34 and lower among oligosymptomatic or asymptomatic cases. Assuming a 24-hour time to results for RT-PCR, the cumulative sensitivity of an anterior nares swab rapid antigen test was .70% and almost 90% after 4 days. Conclusions. The near-immediate time to results for antigen tests significantly offsets lower analytical sensitivity in settings where RT-PCR results are delayed or unavailable.
Keywords in Portuguese
Porto VelhoRondônia
Allplex SARS-CoV-2 assay
SalivaDirect
Teste PADRÃO Q COVID-19 Ag
LumiraDx SARS-CoV-2 Ag test
Keywords
Porto VelhoRondônia
Allplex SARS-CoV-2 assay
SalivaDirect
SD Biosensor STANDARD Q COVID-19 Ag
LumiraDx SARS-CoV-2 Ag test
Keywords in Spanish
Porto VelhoRondônia
Ensayo Allplex SARS-CoV-2
SalivaDirect
SD Biosensor STANDARD Q COVID-19 Ag
La Prueba LumiraDx SARS-CoV-2 Ag
DeCS
SARS-CoV-2COVID-19
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Kit de Reagentes para Diagnóstico
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