Author | Rodrigues, Júlia Alves Nascimento | |
Author | Borges, Leonardo Luiz | |
Access date | 2022-06-08T19:33:38Z | |
Available date | 2022-06-08T19:33:38Z | |
Document date | 2022 | |
Citation | RODRIGUES, Júlia Alves Nascimento; BORGES, Leonardo Luiz. In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential. Revista Fitos, v. 16, n. 1, p. 9-17, Mar. 2022. | en_US |
ISSN | 1808-9569 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/53134 | |
Language | eng | en_US |
Publisher | Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde. | en_US |
Rights | open access | |
Title | In silico search of Myrcia tomentosa (Myrtaceae) antineoplastic potential | en_US |
Type | Article | en_US |
DOI | 10.32712/2446-4775.2022.1137 | |
Abstract | Myrcia tomentosa, popularly known as “guava-brava”, belongs to the Myrtaceae family, widely used in folk medicine to treat various diseases. There already are studies proving the effectiveness of several of its components. However, there are few specific articles on the biological potential of M. tomentosa compounds. The aim of this study was to evaluate the potential antineoplastic activity from M. tomentosa. For these, we performed in silico analysis to evaluate pharmacological and toxicological activities, besides the interaction between M. tomentosa molecules with the human targets from redocking analysis. Our results showed that α-cadinol was the highest score molecule between the 11 compounds present in screening analysis. Among its possible actions, antineoplastic activity and interaction with cytochrome P450 19 A1 were found. This cytochrome was related to breast cancer and is the main target of the antineoplastic drugs used in this cancer’s treatment. Therefore, we believe that α-cadinol should be considered in future in vitro and in vivo assays against breast cancer. | en_US |
Affilliation | Pontifícia Universidade Católica de Goiás. Escola de Ciências Médicas e da Vida. Goiânia, GO, Brasil. | |
Affilliation | Pontifícia Universidade Católica de Goiás. Escola de Ciências Médicas e da Vida. Goiânia, GO, Brasil / Universidade Estadual de Goiás. Anápolis, GO, Brasil. | |
Subject | Breast cancer | en_US |
Subject | Medicinal plants | en_US |
Subject | α-cadinol | en_US |
Subject | Molecular docking | en_US |
e-ISSN | 2446-4775 | |