Author | Soares, Esmeralda A. J. M. | |
Author | Martínez, Ana M. B. | |
Author | Souza, Thatiana M. | |
Author | Santos, André F. A. | |
Author | Hora, Vanusa da | |
Author | Silveira, Jussara | |
Author | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
Author | Tanuri, Amilcar | |
Author | Soares, Marcelo A. | |
Access date | 2010-08-23T16:48:28Z | pt_BR |
Access date | 2010-11-04T14:19:42Z | |
Available date | 2010-08-23T16:48:28Z | pt_BR |
Available date | 2010-11-04T14:19:42Z | |
Document date | 2005 | pt_BR |
Citation | SOARES, E. A. J. M. et al. HIV-1 subtype C dissemination in southern Brazil. AIDS, London, v. 19, p. S81–S86, 2005. Suppl. 4. | pt_BR |
ISSN | 0269-9370 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/530 | |
Language | eng | pt_BR |
Publisher | Lippincott Williams & Wilkins | pt_BR |
Rights | open access | pt_BR |
Title | HIV-1 subtype C dissemination in southern Brazil | pt_BR |
Type | Article | |
DOI | 10.1097/01.aids.0000191497.00928.e4 | pt_BR |
Abstract | Objectives: To describe the molecular and epidemiological profile of HIV-1 in patients followed at the University Hospital of Rio Grande, Brazil. Design and methods: A cross-sectional study was conducted from September to December 2002. Plasma viral RNA of 85 patients was extracted and protease and reverse transcriptase genes were polymerase chain reaction-amplified and sequenced. Sequences were subtyped and examined to antiretroviral resistance mutations. Laboratory data and past history of antiretroviral treatment were also collected. Results: Most viruses were either subtype B (42%) or subtype C (45%). No risk behaviour, sexual orientation or laboratory parameter was associated with any specific subtype, but subtype C tended to be more frequently found in women (P ¼ 0.06). The prevalence of subtype C has increased over the HIV/AIDS epidemic, accounting for almost 60% of cases diagnosed in 2002. Intra-subtype genetic distances were smaller in subtype C than in subtype B, suggesting a more recent introduction of the former in the epidemic. Of patients under treatment, 60% had at least one antiretroviral drug resistance mutation, but no mutation was specifically associated with any HIV-1 subtype. Only one resistance mutation each was found in drug-naive patients with subtypes B and C. Conclusion: Despite the fact that subtype C appeared in southern Brazil more recently than subtype B, it is now the predominant strain in Rio Grande. The epidemic spread of subtype C could be taking place in Brazil, and possibly in south America, a phenomenon similar to that seen in other countries where this subtype is now totally dominant. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Universidade Federal do Rio Grande. Departamento de Patologia. Rio Grande, RS, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Universidade Federal do Rio Grande. Departamento de Patologia. Rio Grande, RS, Brasil. | pt_BR |
Affilliation | Fundação Universidade Federal do Rio Grande. Departamento de Patologia. Rio Grande, RS, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Molecular epidemiology | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Southern Brazil | pt_BR |
Subject | Subtype C | pt_BR |