Author | Tibúrcio, Rafael | |
Author | Narendran, opalan | |
Author | Duarte, Beatriz Barreto | |
Author | Queiroz, Artur T. L. | |
Author | Pereira, Mariana Araújo | |
Author | Anbalagan, Selvaraj | |
Author | Nayak, Kaustuv | |
Author | Ravichandran, Narayanan | |
Author | Subramani, Rajasekaran | |
Author | Antonelli, Lis R. V. | |
Author | Satagopan, Kumar | |
Author | Anbalagan, Komathi | |
Author | Porter, Brian O. | |
Author | Sher, Alan | |
Author | Swaminathan, Soumya | |
Author | Sereti, Irini | |
Author | Andrade, Bruno B. | |
Access date | 2022-04-07T12:26:41Z | |
Available date | 2022-04-07T12:26:41Z | |
Document date | 2022 | |
Citation | TIBÚRCIO, Rafael et al. Frequency of CXCR3+ CD8+ T-lymphocyte subsets in peripheral blood Is associated with the risk of paradoxical tuberculosis-associated Immune reconstitution inflammatory syndrome development in advanced HIV disease. Frontiers in Immunology, v. 13, p. 1-13, 2022. | pt_BR |
ISSN | 1664-3224 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/52076 | |
Sponsorship | Programa do Instituto Nacional de Alergias e Infecções Doenças. programa de pesquisa Cooperativa EUA-Índia. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Programa de Pesquisa Intramural da Fundação Oswaldo Cruz (FIOCRUZ) e a Fundação Nacional Conselho de Desenvolvimento Científico e Tecnológico (CNPq). | pt_BR |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Memória Imunológica | pt_BR |
Subject in Portuguese | Tuberculose | pt_BR |
Title | Frequency of CXCR3+ CD8+ T-lmphocyte subsets in peripheral blood Is associated with the risk of pradoxical tuberculosis-associated immune reconstitution inflammatory syndrome development in advanced HIV disease | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fimmu.2022.873985 | |
Abstract | Background: Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a clinical aggravation of TB symptoms observed among a fraction of HIV coinfected patients shortly after the start of antiretroviral therapy (ART). Of note, TB-IRIS is characterized by exacerbated inflammation and tissue damage that occurs in response to the elevated production of CD4+ T cell-derived IFN-γ. Nevertheless, the possible participation of CD8+ T cells in TB-IRIS development remains unclear. ethods: We performed a comprehensive assessment of the composition of CD8+ T cell memory subsets and their association with circulating inflammation-related molecules in TB-HIV coinfected patients initiating ART. Results: We found that TB-IRIS individuals display higher frequencies of Antigen-experienced CD8+ T cells during the onset of IRIS and that the levels of these cells positively correlate with baseline mycobacterial smear grade. TB-IRIS individuals exhibited higher frequencies of effector memory and lower percentages of naïve CD8+ T cells than their Non-IRIS counterparts. In both TB-IRIS and Non-IRIS patients, ART commencement was associated with fewer significant correlations among memory CD8+ T cells and cells from other immune compartments. Networks analysis revealed distinct patterns of correlation between each memory subset with inflammatory cytokines suggesting different dynamics of CD8+ T cell memory subsets reconstitution. TB-IRIS patients displayed lower levels of memory cells positive for CXCR3 (a chemokine receptor that plays a role in trafficking activated CD8+ T cells to the tissues) than Non-IRIS individuals before and after ART. Furthermore, we found that CXCR3+ naïve CD8+ T cells were inversely associated with the risk of TB-IRIS development. On the other hand, we noticed that the frequencies of CXCR3+ effector CD8+ T cells were positively associated with the probability of TB-IRIS development. Conclusion: Our data suggest that TB-IRIS individuals display a distinct profile of memory CD8+ T cell subsets reconstitution after ART initiation. Moreover, our data point to a differential association between the frequencies of CXCR3+ CD8+ T cells and the risk of TB-IRIS development. Collectively, our findings lend insights into the potential role of memory CD8+ T cells in TB-IRIS pathophysiology. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores, Salvador, BA, Brasil / Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica, Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Department of Clinical Research. National Institute for Research in Tuberculosis. Chennai, Índia. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores, Salvador, BA, Brasil / Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica, Salvador, BA, Brasil / Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica, Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores, Salvador, BA, Brasil / Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica, Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Department of Clinical Research. National Institute for Research in Tuberculosis. Chennai, Índia. | pt_BR |
Affilliation | Department of Clinical Research. National Institute for Research in Tuberculosis. Chennai, Índia. / ICGEB-Emory Vaccine Centre. International Centre for Genetic Engineering and Biotechnology. New Delhi, India, | pt_BR |
Affilliation | Government Hospital of Thoracic Medicine. Chennai, Índia. | pt_BR |
Affilliation | Department of Clinical Research. National Institute for Research in Tuberculosis. Chennai, Índia. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitarias. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Government Hospital of Thoracic Medicine. Chennai, Índia. | pt_BR |
Affilliation | Government Hospital of Thoracic Medicine. Chennai, Índia. | pt_BR |
Affilliation | HIV Pathogenesis Section. Laboratory of Immunoregulation. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, United States. | pt_BR |
Affilliation | Immunobiology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, United States. | pt_BR |
Affilliation | Department of Clinical Research. National Institute for Research in Tuberculosis. Chennai, Índia. | pt_BR |
Affilliation | HIV Pathogenesis Section. Laboratory of Immunoregulation. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, United States. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores, Salvador, BA, Brasil / Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica, Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil / Wellcome Trust Centre for Infectious Disease Research in Africa. Institute of Infectious Disease and Molecular Medicine. University of Cape Town. Cape Town, South Africa / Escola Bahiana de Medicina e Saúde Pública. Curso de Medicina. Salvador, BA, Brasil / Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine. Nashville, TN, United States. | pt_BR |
Subject | Immunologic Memory | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject in Spanish | Memoria Inmunológica | pt_BR |
Subject in Spanish | Tuberculosis | pt_BR |
Subject in French | Mémoire immunologique | pt_BR |
Subject in French | Tuberculose | pt_BR |