Author | Bastard, Paul | |
Author | Michailidis, Eleftherios | |
Author | Hoffmann, Hans-Heinrich | |
Author | Chbihi, Marwa | |
Author | Le Voyer, Tom | |
Author | Rosain, Jérémie | |
Author | Philippot, Quentin | |
Author | Seeleuthner, Yoann | |
Author | Gervais, Adrian | |
Author | Materna, Marie | |
Author | Oliveira, Patricia Mouta Nunes de | |
Author | Maia, Maria de Lourdes S. | |
Author | Ano Bom, Ana Paula Dinis | |
Author | Azamor, Tamiris | |
Author | Conceição, Deborah Araújo da | |
Author | Goudouris, Ekaterini | |
Author | Homma, Akira | |
Author | Slesak, Günther | |
Author | Schäfer, Johannes | |
Author | Pulendran, Bali | |
Author | Miller, Joseph D. | |
Author | Huits, Ralph | |
Author | Yang, Rui | |
Author | Rosen, Lindsey B. | |
Author | Bizien, Lucy | |
Author | Lorenzo, Lazaro | |
Author | Chrabieh, Maya | |
Author | Erazo, Lucia V. | |
Author | Rozenberg, Flore | |
Author | Jeljeli, Mohamed Maxime | |
Author | Béziat, Vivien | |
Author | Holland, Steven M. | |
Author | Cobat, Aurélie | |
Author | Notarangelo, Luigi D. | |
Author | Su, Helen C. | |
Author | Ahmed, Rafi | |
Author | Puel, Anne | |
Author | Zhang, Shen-Ying | |
Author | Abel, Laurent | |
Author | Seligman, Stephen J. | |
Author | Zhang, Qian | |
Author | MacDonald, Margaret R. | |
Author | Jouanguy, Emmanuelle | |
Author | Rice, Charles M. | |
Author | Casanova, Jean-Laurent | |
Access date | 2022-02-21T14:41:50Z | |
Available date | 2022-02-21T14:41:50Z | |
Document date | 2021 | |
Citation | BASTARD, Paul et al. Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine. Journal of Experimental Medicine, v. 2018, n. 4, p. 1-16, e20202486, 2021. | pt_BR |
ISSN | 0022-1007 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/51336 | |
Abstract in Portuguese | A vacina viva atenuada do vírus da febre amarela (YFV) pode, em casos raros, causar doença com risco de vida, geralmente em pacientes sem história prévia de doença viral grave. A deficiência completa de IFNAR1 autossômica recessiva (AR) foi relatada em um paciente de 12 anos de idade. Aqui, nós estudamos sete outros pacientes previamente saudáveis com idades entre 13 e 80 anos com doença inexplicável associada à vacina YFV com risco de vida. Um paciente de 13 anos tinha deficiência completa de IFNAR2 de AR. Três outros pacientes vacinados com idades de 47, 57 e 64 anos apresentaram altos títulos de auto-Abs circulantes contra pelo menos 14 dos 17 IFNs do tipo I individuais. Esses anticorpos foram recentemente demonstrados como subjacentes a pelo menos 10% dos casos de pneumonia COVID-19 com risco de vida. Os auto-Abs foram neutralizantes in vitro, bloqueando o efeito protetor do IFN-α2 contra cepas vacinais de YFV. A deficiência de AR IFNAR1 ou IFNAR2 e auto-Abs neutralizantes contra IFNs do tipo I foram responsáveis por mais da metade dos casos de doença associada à vacina YFV com risco de vida estudados aqui. Indivíduos previamente saudáveis podem ser testados para ambas as predisposições antes da vacinação anti-YFV. | pt_BR |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Febre amarela | pt_BR |
Subject in Portuguese | Vacina | pt_BR |
Subject in Portuguese | Anticorpos | pt_BR |
Title | Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine | pt_BR |
Type | Article | pt_BR |
DOI | 10.1084/jem.20202486 | pt_BR |
Abstract | Yellow fever virus (YFV) live attenuated vaccine can, in rare cases, cause life-threatening disease, typically in patients with no previous history of severe viral illness. Autosomal recessive (AR) complete IFNAR1 deficiency was reported in one 12-yr-old patient. Here, we studied seven other previously healthy patients aged 13 to 80 yr with unexplained life-threatening YFV vaccine–associated disease. One 13-yr-old patient had AR complete IFNAR2 deficiency. Three other patients vaccinated at the ages of 47, 57, and 64 yr had high titers of circulating auto-Abs against at least 14 of the 17 individual type I IFNs. These antibodies were recently shown to underlie at least 10% of cases of life-threatening COVID-19 pneumonia. The auto-Abs were neutralizing in vitro, blocking the protective effect of IFN-α2 against YFV vaccine strains. AR IFNAR1 or IFNAR2 deficiency and neutralizing auto-Abs against type I IFNs thus accounted for more than half the cases of life-threatening YFV vaccine-associated disease studied here. Previously healthy subjects could be tested for both predispositions before anti-YFV vaccination. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. / St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Virology and Infectious Disease. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Virology and Infectious Disease. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. | pt_BR |
Affilliation | Ministry of Health. Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Ministry of Health. Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Ministry of Health. Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratory of Immunological Techniques. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Ministry of Health. Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratory of Immunological Techniques. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Ministry of Health. Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Ministry of Health. Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Tropical Medicine Department. Tropenklinik Paul-Lechler-Krankenhaus. Tübingen, Germany. | pt_BR |
Affilliation | Tropical Medicine Department. Tropenklinik Paul-Lechler-Krankenhaus. Tübingen, Germany. | pt_BR |
Affilliation | Emory Vaccine Center and the Department of Microbiology and Immunology. Emory University School of Medicine. Atlanta, GA. / Institute for Immunity, Transplantation and Infection. Department of Pathology. Department of Microbiology and Immunology. Stanford University. Stanford, CA. | pt_BR |
Affilliation | Emory Vaccine Center and the Department of Microbiology and Immunology. Emory University School of Medicine. Atlanta, GA. / Centers for Disease Control and Prevention. National Center for Emerging and Zoonotic Infectious Diseases. Division of Scientific Resources. Atlanta, GA. | pt_BR |
Affilliation | Department of Clinical Sciences. Institute of Tropical Medicine. Antwerp, Belgium. | pt_BR |
Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Clinical Immunology and Microbiology. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. | pt_BR |
Affilliation | Laboratory of Virology. University of Paris. Cochin Hospital. Assistance Publique. Hôpitaux de Paris. Paris, France. | pt_BR |
Affilliation | Laboratory of Immunology. University of Paris. Cochin Hospital. Assistance Publique. Hôpitaux de Paris. Paris, France. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. / St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Clinical Immunology and Microbiology. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Clinical Immunology and Microbiology. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD. | pt_BR |
Affilliation | Laboratory of Clinical Immunology and Microbiology. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD. | pt_BR |
Affilliation | Emory Vaccine Center and the Department of Microbiology and Immunology. Emory University School of Medicine. Atlanta, GA. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. / St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. / St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. / St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. / New York Medical College. Valhalla, NY. | pt_BR |
Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Virology and Infectious Disease. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. / St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Virology and Infectious Disease. The Rockefeller University. New York, NY. | pt_BR |
Affilliation | Laboratory of Human Genetics of Infectious Diseases, Necker Branch. Institut National de la Santé et de la Recherche M´edicale. Necker Hospital for Sick Children. Paris, France. / University of Paris. Imagine Institute. Paris, France. / St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University. New York, NY. / Howard Hughes Medical Institute. New York, NY. | pt_BR |
Subject | Yellow Fever | pt_BR |
Subject | Vaccine | pt_BR |
Subject | Antibodies | pt_BR |
DeCS | Febre Amarela | pt_BR |
DeCS | Vacinas | pt_BR |
DeCS | Anticorpos | pt_BR |
e-ISSN | 1540-9538 | |