Author | Ramirez, Jose Luis | |
Author | Oliveira, Giselle de Almeida | |
Author | Calvo, Eric | |
Author | Dalli, Jesmond | |
Author | Colas, Romain A. | |
Author | Serhan, Charles N. | |
Author | Ribeiro, Jose M. | |
Author | Barillas-Mury, Carolina | |
Access date | 2022-02-04T16:23:24Z | |
Available date | 2022-02-04T16:23:24Z | |
Document date | 2015 | |
Citation | RAMIREZ, Jose Luis et al. A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae. Nat Commun, n. 6, 7403, 2015. doi.org/10.1038/ncomms8403 | pt_BR |
ISSN | 2041-1723 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/51023 | |
Sponsorship | NATIONAL INSTITUTES OF HEALTH | pt_BR |
Language | eng | pt_BR |
Publisher | Nature | pt_BR |
Rights | open access | pt_BR |
Title | A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/ncomms8403 | |
Abstract | "Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of
their immune system to respond to subsequent infections. However, the molecular
mechanism that allows the insect innate immune system to ‘remember’ a previous encounter
with a pathogen has not been established. Challenged mosquitoes constitutively release a
soluble haemocyte differentiation factor into their haemolymph that, when transferred into
Naive mosquitoes, also induces priming. Here we show that this factor consists of a Lipoxin/
Lipocalin complex. We demonstrate that innate immune priming in mosquitoes involves a
persistent increase in expression of Evokin (a lipid carrier of the lipocalin family), and in their
ability to convert arachidonic acid to lipoxins, predominantly Lipoxin A4. Plasmodium ookinete
midgut invasion triggers immune priming by inducing the release of a mosquito lipoxin/
lipocalin complex." | pt_BR |
Affilliation | Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, 20852, Maryland, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brazil/Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA | pt_BR |
Affilliation | Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA | pt_BR |
Affilliation | Department of Anesthesiology. Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine. Brigham and Women’s Hospital and Harvard Medical School. Boston, Massachusetts, USA | pt_BR |
Affilliation | Department of Anesthesiology. Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine. Brigham and Women’s Hospital and Harvard Medical School. Boston, Massachusetts, USA | pt_BR |
Affilliation | Department of Anesthesiology. Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine. Brigham and Women’s Hospital and Harvard Medical School. Boston, Massachusetts, USA | pt_BR |
Affilliation | Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA | pt_BR |
Affilliation | Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA | pt_BR |