Author | Chaves, Lana Bitencourt | |
Author | Guimarães, Glaucia de Oliveira | |
Author | Silva, Daiana de Souza Perce da | |
Author | Banic, Dalma Maria | |
Author | Totino, Paulo Renato Rivas | |
Author | Machado, Ricardo Luiz Dantas | |
Author | Silva, Rodrigo Nunes Rodrigues da | |
Author | Pratt-Riccio, Lilian Rose | |
Author | Ribeiro, Cláudio Tadeu Daniel | |
Author | Lima Junior, Josué da Costa | |
Access date | 2022-01-27T18:34:04Z | |
Available date | 2022-01-27T18:34:04Z | |
Document date | 2021 | |
Citation | CHAVES, Lana Bitencourt et al. Genetic Diversity of Plasmodium vivax Cysteine-Rich Protective Antigen (PvCyRPA) in Field Isolates from Five Different Areas of the Brazilian Amazon. Genes, v. 12, 1657, p. 1 - 18, Oct. 2021. | pt_BR |
ISSN | 2073-4425 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50922 | |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Malária | pt_BR |
Subject in Portuguese | Plasmodium vivax | pt_BR |
Subject in Portuguese | Amazônia brasileira | pt_BR |
Subject in Portuguese | Diversidade genética | pt_BR |
Subject in Portuguese | Prediction | pt_BR |
Subject in Portuguese | Candidato a vacina | pt_BR |
Title | Genetic Diversity of Plasmodium vivax Cysteine-Rich Protective Antigen (PvCyRPA) in Field Isolates from Five Different Areas of the Brazilian Amazon | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/ genes12111657 | |
Abstract | The Plasmodium vivax Cysteine-Rich Protective Antigen (PvCyRPA) has an important role
in erythrocyte invasion and has been considered a target for vivax malaria vaccine development.
Nonetheless, its genetic diversity remains uncharted in Brazilian malaria-endemic areas. Therefore,
we investigated the pvcyrpa genetic polymorphism in 98 field isolates from the Brazilian Amazon and
its impact on the antigenicity of predicted B-cell epitopes. Genetic diversity parameters, population
genetic analysis, neutrality test and the median-joining network were analyzed, and the potential
amino acid polymorphism participation in B-cell epitopes was investigated. One synonymous and
26 non-synonymous substitutions defined fifty haplotypes. The nucleotide diversity and Tajima’s
D values varied across the coding gene. The exon-1 sequence had greater diversity than those of
exon-2. Concerning the prediction analysis, seven sequences were predicted as linear B cell epitopes,
the majority contained in conformational epitopes. Moreover, important amino acid polymorphism
was detected in regions predicted to contain residues participating in B-cell epitopes. Our data
suggest that the pvcyrpa gene presents a moderate polymorphism in the studied isolates and such
polymorphisms alter amino acid sequences contained in potential B cell epitopes, an important
observation considering the antigen potentiality as a vaccine candidate to cover distinct P. vivax
endemic areas worldwide. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Centro Universitário Arthur Sá Earp Neto. Laboratório de Imunologia Básica e Aplicada. Petrópolis, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia de Imunobiologia. Laboratório de Anticorpos Monoclonais.Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Malaria | pt_BR |
Subject | Brazilian Amazon | pt_BR |
Subject | Plasmodium vivax | pt_BR |
Subject | PvCyRPA | pt_BR |
Subject | Genetic diversity | pt_BR |
Subject | Prediction | pt_BR |
Subject | Vaccine candidate | pt_BR |