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https://www.arca.fiocruz.br/handle/icict/50580
ASSESSMENT OF CHEMOKINE SERUM LEVELS IN EPITHELIAL OVARIAN CANCER PATIENTS
Author
Affilliation
Department of Obstetric,Gynecology and Mastology.Botucatu Medical School, UNESP. São Paulo State University, Botucatu, SP
Laboratory of Biomarkers and Monitoring Diagnosis. Rene Rachou Research Center.Oswaldo Cruz Foundation. Belo Horizonte, MG, Brasil
Department of Obstetrics and Gynecology. Federal University of Minas Gerais. Belo Horizonte, MG, Brasil
Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil
Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil
Pró-Criar Clinic of Assisted Reproduction. MaterDei Hospital. Belo Horizonte, MG, Brazil
Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil
Department of Obstetrics, Gynecology and Mastology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, SP
Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil/ Department of Obstetrics and Gynecology. Federal University of Minas Gerais. Belo Horizonte, MG, Brasil
Laboratory of Biomarkers and Monitoring Diagnosis. Rene Rachou Research Center.Oswaldo Cruz Foundation. Belo Horizonte, MG, Brasil
Department of Obstetrics and Gynecology. Federal University of Minas Gerais. Belo Horizonte, MG, Brasil
Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil
Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil
Pró-Criar Clinic of Assisted Reproduction. MaterDei Hospital. Belo Horizonte, MG, Brazil
Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil
Department of Obstetrics, Gynecology and Mastology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, SP
Department of Obstetrics, Gynecology and Mastology. Botucatu Medical School. UNESP. São Paulo State University, Botucatu, SP, Brasil/ Department of Obstetrics and Gynecology. Federal University of Minas Gerais. Belo Horizonte, MG, Brasil
Abstract
Aims and background: The study was undertaken to investigate CCL2/MCP-1, CCL3/MIP-l alpha, CCL4/MIP-1 beta, CCL5/RANTES and CXCL8/IL-8 women with epithelial ovarian cancer.
Methods and study design: Sixteen patients diagnosed with epithelial ovarian cancer and 18 healthy women with no evidence of malign neoplasia (control group) aged from 23 to 89 years (mean +/- SEM, 58.7 +/- 2.3) were included. The epithelial ovarian cancer patients underwent laparotomy and debulking surgery Chemokines serum levels were measured by cytometric bead array. Statistical analysis was performed using Mann-Whitney and Kendall's tau. P <0.05 was considered statistically significant for all analyses.
Results: The tumor staging (FIGO) was classified into: I in 4 cases (25%), III in 5 cases (31.3%) and stage IV in 7 cases (43.8%). Sera chemokine dosages of CCL2 /MCP-1 and CCL4/MIP-1 beta were lower in epithelial ovarian cancer patients than in the control group (P = 0.021 and P = 0.030, respectively). No significant difference between groups was observed in the levels of CCL3/MIP-l alpha, CCL5/RANTES and CXCL8/IL-8. No association between the chemokines analyzed and tumor stage was found. The serum level of CCL4/MIP-1 beta was correlated with CA-125.
Conclusions: The study of serum levels of CCL2/MCP-1, CCL3/MIP-l alpha, CCL4/MIP-1 beta, CCL5/RANTES and CXCL8/IL-8 chemokines in epithelial ovarian cancer patients identified a down-regulation in CCL2/MCP-1 and CCL4/MIP-1 beta, which suggests that the two chemokines may play an important role in the pathophysiology of ovarian cancer.
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