Author | Moll-Bernardes, Renata | |
Author | Sousa, Andrea Silvestre de | |
Author | Macedo, Ariane V. S. | |
Author | Lopes, Renato D. | |
Author | Vera, Narendra | |
Author | Maia, Luciana C. R. | |
Author | Feldman, André | |
Author | Arruda, Guilherme D. A. S. | |
Author | Castro, Mauro J. C. | |
Author | Pimentel-Coelho, Pedro M. | |
Author | Albuquerque, Denílson C. de | |
Author | Paula, Thiago Ceccatto de | |
Author | Furquim, Thyago A. B. | |
Author | Loures, Vitor A. | |
Author | Giusti, Karla G. D. | |
Author | Oliveira, Nathália M. de | |
Author | De Luca, Fábio A. | |
Author | Kotsugai, Marisol D. M. | |
Author | Domiciano, Rafael A. M. | |
Author | Santos, Mayara Fraga | |
Author | Souza, Olga Ferreira de | |
Author | Bozza, Fernando A. | |
Author | Luiz, Ronir Raggio | |
Author | Medei, Emiliano | |
Access date | 2021-12-28T13:42:35Z | |
Available date | 2021-12-28T13:42:35Z | |
Document date | 2021 | |
Citation | MOLL-BERNARDES, Renata et al. IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial. Frontiers in cardiovascular medicine, v. 8, p. 1-10, 2021 | pt_BR |
ISSN | 2297-055X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50537 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Title | IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fcvm.2021.702507 | |
Abstract | Background: Cardiovascular comorbidities such as hypertension and inflammatory response dysregulation are associated with worse COVID-19 prognoses. Different cytokines have been proposed to play vital pathophysiological roles in COVID-19 progression, but appropriate prognostic biomarkers remain lacking. We hypothesized that the combination of immunological and clinical variables at admission could predict the clinical progression of COVID-19 in hypertensive patients. Methods: The levels of biomarkers, including C-reactive protein, lymphocytes, monocytes, and a panel of 29 cytokines, were measured in blood samples from 167 hypertensive patients included in the BRACE-CORONA trial. The primary outcome was the highest score during hospitalization on the modified WHO Ordinal Scale for Clinical Improvement. The probability of progression to severe disease was estimated using a logistic regression model that included clinical variables and biomarkers associated significantly with the primary outcome. Results: During hospitalization, 13 (7.8%) patients showed progression to more severe forms of COVID-19, including three deaths. Obesity, diabetes, oxygen saturation, lung involvement on computed tomography examination, the C-reactive protein level, levels of 15 cytokines, and lymphopenia on admission were associated with progression to severe COVID-19. Elevated levels of interleukin-10 and interleukin-12 (p70) combined with two or three of the abovementioned clinical comorbidities were associated strongly with progression to severe COVID-19. The risk of progression to severe disease reached 97.5% in the presence of the five variables included in our model. Conclusions: This study demonstrated that interleukin-10 and interleukin-12 (p70) levels, in combination with clinical variables, at hospital admission are key biomarkers associated with an increased risk of disease progression in hypertensive patients with COVID-19. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Hospital São Luiz Jabaquara. São Paulo, SP, Brasil / Santa Casa de São Paulo. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Duke University Medical Center. Duke Clinical Research Institute. Durham, NC, United States / Instituto Brasileiro de Pesquisa Clínica. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Hospital São Luiz Anália Franco. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Hospital São Luiz São Caetano. São Caetano do Sul, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Departamento de Cardiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital São Luiz Jabaquara. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Hospital Sino Brasileiro. Osasco, SP, Brasil. | pt_BR |
Affilliation | Hospital São Luiz Anália Franco. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Hospital Villa Lobos. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Hospital Villa Lobos. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Hospital São Luiz Morumbi. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Hospital São Luiz Morumbi. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Hospital São Luiz Anália Franco. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Hospital Copa Star. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Estudos em Saúde Pública. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro Nacional de Biologia Estrutural e Bioimagem. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | COVID-19 | pt_BR |
Subject | Biomarker | pt_BR |
Subject | Cytokine | pt_BR |
Subject | Hypertension | pt_BR |
Subject | Inflammation | pt_BR |
Subject | Prognosis | pt_BR |