Author | Foo, Suan-Sin | |
Author | Cambou, Mary Catherine | |
Author | Mok, Thalia | |
Author | Fajardo, Viviana M. | |
Author | Jung, Kyle L. | |
Author | Fuller, Trevon | |
Author | Chen, Weiqiang | |
Author | Kerin, Tara | |
Author | Mei, Jenny | |
Author | Bhattacharya, Debika | |
Author | Choi, Younho | |
Author | Wu, Xin | |
Author | Xia, Tian | |
Author | Shin, Woo-Jin | |
Author | Cranston, Jessica | |
Author | Aldrovandi, Grace | |
Author | Tobin, Nicole | |
Author | Contreras, Deisy | |
Author | Ibarrondo, Francisco J. | |
Author | Yang, Otto | |
Author | Yang, Shangxin | |
Author | Garner, Omai | |
Author | Cortado, Ruth | |
Author | Bryson, Yvonne | |
Author | Janzen, Carla | |
Author | Ghosh, Shubhamoy | |
Author | Devaskar, Sherin | |
Author | Asilnejad, Brenda | |
Author | Moreira, Maria Elisabeth | |
Author | Vasconcelos, Zilton Farias Meira de | |
Author | Soni, Priya R. | |
Author | Gibson, L. Caroline | |
Author | Brasil, Patricia | |
Author | Comhair, Suzy A. A. | |
Author | Arumugaswami, Vaithilingaraja | |
Author | Erzurum, Serpil C. | |
Author | Rao, Rashmi | |
Author | Jung, Jae U. | |
Author | Nielsen-Saines, Karin | |
Access date | 2021-12-15T16:43:09Z | |
Available date | 2021-12-15T16:43:09Z | |
Document date | 2021 | |
Citation | FOO, Suan-Sin et al. The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2. Cell Reports Medicine, v. 2, n. 11, p. 1-25, Nov. 2021. | pt_BR |
ISSN | 2666-3791 | |
URI | https://www.arca.fiocruz.br/handle/icict/50451 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2 | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.xcrm.2021.100453 | |
Abstract | While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and ESM1 and reducing BGN and CD209. Finally, COVID-19-exposed infants exhibit induction of T cell-associated cytokines (IL33, NFATC3, and CCL21), while some undergo IL-1β/IL-18/CASP1 axis-driven neonatal respiratory distress despite birth at term. Our findings demonstrate COVID-19-induced immune rewiring in both mothers and neonates, warranting long-term clinical follow-up to mitigate potential health risks. | pt_BR |
Affilliation | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Neonatology. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA. | pt_BR |
Affilliation | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Affilliation | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Affilliation | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Affilliation | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Department of Pathology and Laboratory Medicine. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Department of Pathology and Laboratory Medicine. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Neonatology. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Neonatology. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | Georgetown University. School of Medicine. Washington, DC, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Cedars-Sinai Medical Center. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | Cedars-Sinai Medical Center. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Cleveland Clinic. Lerner Research Institute. Respiratory Institute. Cleveland, OH, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Department of Molecular and Medical Pharmacology. Los Angeles, CA, USA. | pt_BR |
Affilliation | Cleveland Clinic. Lerner Research Institute. Respiratory Institute. Cleveland, OH, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA. | pt_BR |
Affilliation | Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA. | pt_BR |
Affilliation | University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA. | pt_BR |
Subject | COVID-19 | pt_BR |
Subject | Exposed infants | pt_BR |
Subject | IFN-λ signaling | pt_BR |
Subject | Mother-infant pairs | pt_BR |
Subject | Pregnancy | pt_BR |
Subject | Prenatal SARS-CoV-2 infection | pt_BR |
Subject | Serum proteomics | pt_BR |
Subject | SARS-CoV-2 | |