Author | Ticona, Juan P. Aguilar | |
Author | Nery Junior, Nivison | |
Author | Ladines-Lim, Joseph B. | |
Author | Gambrah, Claudia | |
Author | Sacramento, Gielson | |
Author | Freitas, Bruno de Paula | |
Author | Bouzon, Joseane | |
Author | Oliveira Filho, Jamary | |
Author | Borja, Ana | |
Author | Adhikarla, Haritha | |
Author | Montoya, Magelda | |
Author | Chin, Athena | |
Author | WunderJunior, Elsio A. | |
Author | Ballalai, Verena | |
Author | Vieira, Carina | |
Author | Belfort, Rubens | |
Author | AlmeidaI, Antonio R. P. | |
Author | Reis, Mitermayer Galvão dos | |
Author | HarrisID, Eva | |
Author | Ko, Albert Icksang | |
Author | Costa, Federico | |
Access date | 2021-12-10T11:26:17Z | |
Available date | 2021-12-10T11:26:17Z | |
Document date | 2021 | |
Citation | TICONA, Juan P. Aguilar et al. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLoS Neglected Tropical Diseases, 2021. | pt_BR |
ISSN | 1935-2735 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50277 | |
Description | 1 Instituto de Sau´de Coletiva, Universidade Federal da Bahia, Salvador, Brazil, 2 Instituto Gonc¸alo Moniz,
Fundac¸ão Oswaldo Cruz,Ministe´ rio da Sau´de, Salvador, Brazil, 3 Department of Epidemiology of Microbial
Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America, 4 Hospital Geral
Roberto Santos (HGRS), Salvador, Brazil, 5 Faculdade de Medicina, Universidade Federal de São Paulo,
São Paulo, Brazil, 6 Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil,
7 Programa de Pòs-Graduac¸ão em Ciencias da Saude (PPgCS) Universidade Federal da Bahia, Salvador,
Brazil, 8 Departamento de Fonoaudiologia. Instituto de Ciências da Sau´de. Universidade Federal da Bahia,
Salvador, Brazil, 9 Division of Infectious Diseases and Vaccinology, School of Public Health, University of
California, Berkeley, California, United States of America | pt_BR |
Sponsorship | National Institutes of Health (NIAID R01
AI052473 (AK), R25 U01AI088752 (AK), FIC R01
TW009504 (AK), R25 TW009338 (AK), F31
AI114245 (AK), R01 AI121207 (AK), D43
TW010540 (AK), P01 AI106695 (EH) (https://www.
niaid.nih.gov/), Wellcome Trust (102330/Z/13/Z https://wellcome.ac.uk/), Bahia State Research
Support Foundation (FAPESB) ZIKA-FAPESB T.O. n
˚ PET0021/2016 (www.fapesb.ba.gov.br) and
Coordination for the Improvement of Higher
Education (CAPES) from Brazil (https://www.capes.
gov.br/). | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Zika virus | pt_BR |
Subject in Portuguese | Microcefalia | pt_BR |
Subject in Portuguese | Anticorpos Monoclonais | pt_BR |
Subject in Portuguese | Anormalidades Congênitas | pt_BR |
Title | Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal. pntd.0009162 | |
Abstract | The prevalence of developmental alterations associated with in-utero Zika virus (ZIKV)
exposure in children is not well understood. Furthermore, estimation of the Population Attributable
Fraction (PAF) of developmental alterations attributed to ZIKV has not been performed
due to lack of population-based cohorts with data on symptomatic and
asymptomatic ZIKV exposures and an appropriate control group. The aim of this study was
to characterize neurodevelopmental outcomes of children at 11 to 32 months of age with
intrauterine ZIKV exposure and estimate the PAF of alterations secondary to ZIKV
exposure.
Methodology/Principal findings
We performed a cohort of biannual community-based prospective serosurveys in a slum
community in Salvador, Brazil. We recruited women participating in our cohort, with a documented
pregnancy from January 2015 to December 2016 and children born to those mothers.
Children were classified as ZIKV exposed in utero (born from women with ZIKV
seroconversion during pregnancy) or unexposed (born from women without ZIKV seroconversion
or that seroconverted before/after pregnancy) by using an IgG monoclonal antibody
blockade-of-binding (BoB). We interviewed mothers and performed anthropometric, audiometric,
ophthalmological, neurologic, and neurodevelopmental evaluations of their children at 11 to 32 months of age. Among the 655 women participating in the cohort, 66 (10%) were
pregnant during the study period. 46 (70%) of them completed follow-up, of whom ZIKV
seroconversion occurred before, during, and after pregnancy in 25 (54%), 13 (28%), and 1
(2%), respectively. The rest of women, 7 (21.2%), did not present ZIKV seroconversion. At
11 to 32 months of life, the 13 ZIKV-exposed children had increased risk of mild cognitive
delay (RR 5.1; 95%CI 1.1–24.4) compared with the 33 children unexposed, with a PAF of
53.5%. Exposed children also had increased risk of altered auditory behavior (RR 6.0; 95%
CI 1.3–26.9), with a PAF of 59.5%.
Conclusions
A significant proportion of children exposed in utero to ZIKV developed mild cognitive delay
and auditory behavioral abnormalities even in the absence of gross birth defects such as
microcephaly and other neurodevelopmental domains. Furthermore, our findings suggest
that over half of these abnormalities could be attributed to intrauterine ZIKV exposure. | pt_BR |
Affilliation | "Múltipla ver em Notas" | pt_BR |
Subject | Zika virus | pt_BR |
Subject | Microcephaly | pt_BR |
Subject | Antibodies, Monoclonal | pt_BR |
Subject | Congenital Abnormalities | pt_BR |