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https://www.arca.fiocruz.br/handle/icict/50259
LEISHMANIA-INDUCED DENDRITIC CELL MIGRATION AND ITS POTENTIAL CONTRIBUTION TO PARASITE DISSEMINATION
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hospedeiro - Interação Parasitária e Epidemiologia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hospedeiro - Interação Parasitária e Epidemiologia. Salvador, BA, Brasil.
Federal University of Bahia. Professor Edgard Santos Hospital. Immunology Service. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador. BA, Brazil / D’Or Institute for Research and Education. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador. BA, Brazil / D’Or Institute for Research and Education. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador. BA, Brazil / D’Or Institute for Research and Education. Salvador, BA, Brazil /
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.
Federal University of Bahia. Professor Edgard Santos Hospital. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia. Institute of Health Sciences. Department of Bio-Interaction. Salvador, BA, Brazil.
.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hospedeiro - Interação Parasitária e Epidemiologia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hospedeiro - Interação Parasitária e Epideiologia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hospedeiro - Interação Parasitária e Epidemiologia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hospedeiro - Interação Parasitária e Epidemiologia. Salvador, BA, Brasil.
Federal University of Bahia. Professor Edgard Santos Hospital. Immunology Service. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador. BA, Brazil / D’Or Institute for Research and Education. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador. BA, Brazil / D’Or Institute for Research and Education. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador. BA, Brazil / D’Or Institute for Research and Education. Salvador, BA, Brazil /
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.
Federal University of Bahia. Professor Edgard Santos Hospital. Immunology Service. Salvador, BA, Brazil / Federal University of Bahia. Institute of Health Sciences. Department of Bio-Interaction. Salvador, BA, Brazil.
.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hospedeiro - Interação Parasitária e Epidemiologia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hospedeiro - Interação Parasitária e Epideiologia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hospedeiro - Interação Parasitária e Epidemiologia. Salvador, BA, Brasil.
Abstract
Leishmania, an intracellular parasite species, causes lesions on the skin and in the mucosa
and internal organs. The dissemination of infected host cells containing Leishmania is crucial to
parasite survival and the establishment of infection. Migratory phenomena and the mechanisms
underlying the dissemination of Leishmania-infected human dendritic cells (hDCs) remain poorly
understood. The present study aimed to investigate differences among factors involved in hDC
migration by comparing infection with visceral leishmaniasis (VL) induced by Leishmania infantum
with diverse clinical forms of tegumentary leishmaniasis (TL) induced by Leishmania braziliensis or
Leishmania amazonensis. Following the infection of hDCs by isolates obtained from patients with
different clinical forms of Leishmania, the formation of adhesion complexes, actin polymerization,
and CCR7 expression were evaluated. We observed increased hDC migration following infection
with isolates of L. infantum (VL), as well as disseminated (DL) and diffuse (DCL) forms of cutaneous
leishmaniasis (CL) caused by L. braziliensis and L. amazonensis, respectively. Increased expression
of proteins involved in adhesion complex formation and actin polymerization, as well as higher
CCR7 expression, were seen in hDCs infected with L. infantum, DL and DCL isolates. Together, our
results suggest that hDCs play an important role in the dissemination of Leishmania parasites in the
vertebrate host.
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