Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/50255
UNTARGETED METABOLOMICS INSIGHTS INTO NEWBORNS WITH CONGENITAL ZIKA INFECTION
Author
Nunes, Estéfane da C.
Filippis, Ana M. B. de
Pereira, Taiane do E. S.
Faria, Nieli R. da C.
Salgado, Álvaro
Santos, Cleiton S.
Carvalho, Teresa C. P. X.
Calcagno, Juan I.
Chalhoub, Flávia L. L.
Brown, David
Giovanetti, Marta
Alcantara Junior, Luiz Carlos
Barreto, Fernanda K.
Siqueira, Isadora Cristina de
Canuto, Gisele A. B.
Filippis, Ana M. B. de
Pereira, Taiane do E. S.
Faria, Nieli R. da C.
Salgado, Álvaro
Santos, Cleiton S.
Carvalho, Teresa C. P. X.
Calcagno, Juan I.
Chalhoub, Flávia L. L.
Brown, David
Giovanetti, Marta
Alcantara Junior, Luiz Carlos
Barreto, Fernanda K.
Siqueira, Isadora Cristina de
Canuto, Gisele A. B.
Affilliation
“Múltipla – ver em notas”
Abstract
Abstract: Zika virus (ZIKV), an emerging virus belonging to the Flaviviridae family, causes severe
neurological clinical complications and has been associated with Guillain-Barré syndrome, fetal
abnormalities known collectively as congenital Zika syndrome, and microcephaly. Studies have
shown that ZIKV infection can alter cellular metabolism, directly affecting neural development.
Brain growth requires controlled cellular metabolism, which is essential for cell proliferation and
maturation. However, little is known regarding the metabolic profile of ZIKV-infected newborns and
possible associations related to microcephaly. Furthering the understanding surrounding underlying
mechanisms is essential to developing personalized treatments for affected individuals. Thus,
metabolomics, the study of the metabolites produced by or modified in an organism, constitutes a
valuable approach in the study of complex diseases. Here, 26 serum samples from ZIKV-positive
newborns with or without microcephaly, as well as controls, were analyzed using an untargeted
metabolomics approach involving gas chromatography–mass spectrometry (GC-MS). Significant
alterations in essential and non-essential amino acids, as well as carbohydrates (including aldohexoses,
such as glucose or mannose) and their derivatives (urea and pyruvic acid), were observed in the
metabolic profiles analyzed. Our results provide insight into relevant metabolic processes in patients
with ZIKV and microcephaly.
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