Author | Akenroye, Ayobami T. | |
Author | Brunetti, Tonya | |
Author | Romero, Karina | |
Author | Daya, Michelle | |
Author | Kanchan, Kanika | |
Author | Shankar, Gautam | |
Author | Chavan, Sameer | |
Author | Boorgula, Meher Preethi | |
Author | Ampleford, Elizabeth A. | |
Author | Fonseca, Hellen Freitas | |
Author | Hawkins, Gregory A. | |
Author | Teixeira, Helena Mariana Pitangueira | |
Author | Campbell, Monica | |
Author | Rafaels, Nicholas | |
Author | Winters, Alexandra | |
Author | Bleecker, Eugene R. | |
Author | Cruz, Alvaro A. | |
Author | Barreto, Mauricio Lima | |
Author | Meyers, Deborah A. | |
Author | Ortega, Victor E. | |
Author | Figueiredo, Camila A. | |
Author | Barnes, Kathleen C. | |
Author | Checkley, William | |
Author | Hansel, Nadia N. | |
Author | Mathias, Rasika A. | |
Access date | 2021-12-03T14:33:55Z | |
Available date | 2021-12-03T14:33:55Z | |
Document date | 2021 | |
Citation | AKENROYE, Ayobami T. et al. Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children. Journal of Allergy and Clinical Immunology., 2021. | pt_BR |
ISSN | 0091-6749 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50155 | |
Description | athe Division of Pediatric Allergy and Immunology, cthe Division of Pulmonary
and Critical Care Medicine, ethe Division of Allergy and Clinical Immunology, Johns
Hopkins University School of Medicine, Baltimore; bthe Division of Biomedical Informatics
and Personalized Medicine, University of Colorado, Denver; dthe A.B.
PRISMA, Lima; fthe Department of Internal Medicine, Center for Precision Medicine,
Wake Forest School of Medicine, Winston-Salem; gInstituto de Ci^encias da Sa ude,
Universidade Federal da Bahia (UFBA), Salvador; hthe Department of Biochemistry,
Wake Forest School of Medicine, Winston-Salem; ithe Department of Medicine, University
of Arizona, Tucson; jthe Fundaçãao ProAR, Salvador; kthe Centro de Integraçãao
de Dados e Conhecimento para Sa ude, Fiocruz, Salvador; and lthe Department of International
Health, Program in Global Disease Epidemiology and Control, Johns Hopkins
Bloomberg School of Public Health, Baltimore. | pt_BR |
Sponsorship | National Institute of Environmental Health Sciences, National Institutes of
Health (grants R01ES018845 and R01ES018845-S1 and NHLBI R01 HL142992).
A.T.A was supported by the National Institute of Allergy and Infectious Diseases
T32 Research Training Grant in Pediatric Allergy and Immunology (grant no.
2T32AI007007-41) and the Johns Hopkins University Provost’s Postdoctoral Award.
K.R. was a Fogarty Global Health Fellow through the consortium comprising the University
of North Carolina, Johns Hopkins University, Morehouse School of Medicine,
and Tulane University during the conduct of this work (through grant
5R25TW009340) W.C. was supported by Pathway to Independence Award
R00HL096955 from the National Heart, Lung, and Blood Institute, National Institutes
of Health. | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Asma | pt_BR |
Subject in Portuguese | Imunoglobulina E | pt_BR |
Subject in Portuguese | Função Respiratória | pt_BR |
Subject in Portuguese | Estudo de Associação Genômica Ampla | pt_BR |
Subject in Portuguese | Peru | pt_BR |
Subject in Portuguese | Ancestralidade | pt_BR |
Subject in Portuguese | Alergia | pt_BR |
Title | Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children | pt_BR |
Type | Article | pt_BR |
Abstract | Background: Genetic ancestry plays a role in asthma health
disparities.
Objective: Our aim was to evaluate the impact of ancestry on
and identify genetic variants associated with asthma, total
serum IgE level, and lung function.
Methods: A total of 436 Peruvian children (aged 9-19 years)
with asthma and 291 without asthma were genotyped by using
the Illumina Multi-Ethnic Global Array. Genome-wide
proportions of indigenous ancestry populations from
continental America (NAT) and European ancestry from the
Iberian populations in Spain (IBS) were estimated by using
ADMIXTURE. We assessed the relationship between ancestry
and the phenotypes and performed a genome-wide association
study.
Results: The mean ancestry proportions were 84.7% NAT (case
patients, 84.2%; controls, 85.4%) and 15.3% IBS (15.8%;
14.6%). With adjustment for asthma, NAT was associated with
higher total serum IgE levels (P < .001) and IBS was associated
with lower total serum IgE levels (P < .001). NAT was associated
with higher FEV1 percent predicted values (P < .001), whereas
IBS was associated with lower FEV1 values in the controls but
not in the case patients. The HLA-DR/DQ region on
chromosome 6 (Chr6) was strongly associated with total serum
IgE (rs3135348; P 5 3.438 3 10–10) and was independent of an
association with the haplotype HLA-DQA1 HLADQB1:
04.01 04.02 (P 5 1.55 3 10–05). For lung function, we
identified a locus (rs4410198; P 5 5.536 3 10–11) mapping to
Chr19, near a cluster of zinc finger interacting genes that
colocalizes to the long noncoding RNA CTD-2537I9.5. This novel
locus was replicated in an independent sample of pediatric case
patients with asthma with similar admixture from Brazil (P 5
.005).
Conclusion: This study confirms the role of HLA in atopy, and
identifies a novel locus mapping to a long noncoding RNA for
lung function that may be specific to children with NAT. | pt_BR |
Affilliation | "Múltipla ver em Notas" | pt_BR |
Subject | Asthma | pt_BR |
Subject | Immunoglobulin E | pt_BR |
Subject | Lung function | pt_BR |
Subject | Admixture | pt_BR |
Subject | Genome wide association analyses | pt_BR |
Subject | Peru | pt_BR |
Subject | Ancestry | pt_BR |
Subject | Allergy | pt_BR |
e-ISSN | 10.1016/j.jaci.2021.02.035 | |