Author | Lima, Pedro Antônio Schmidt do Prado | |
Author | Costa-Ferro, Zaquer Suzana Munhoz | |
Author | Souza, Bruno Solano de Freitas | |
Author | Cruz, Ivana Beatrice Manica da | |
Access date | 2021-11-18T18:11:09Z | |
Available date | 2021-11-18T18:11:09Z | |
Document date | 2021 | |
Citation | LIMA, Pedro Antônio Schmidt do Prado et al. Is there a place for cellular therapy in depression? World Journal of Psychiatry, v. 11, n. 9, p. 553-567, 2021. | pt_BR |
ISSN | 2220-3206 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/49872 | |
Sponsorship | Conselho Nacional
de Desenvolvimento Cientifico -
CNPq. | pt_BR |
Language | eng | pt_BR |
Publisher | Baishideng Publishing Group | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Transtornos de Humor | pt_BR |
Subject in Portuguese | Transplante de células-tronco | pt_BR |
Subject in Portuguese | Transplante de células-tronco mesenquimais; | pt_BR |
Subject in Portuguese | Inflamação | pt_BR |
Subject in Portuguese | Imunomodulação | pt_BR |
Subject in Portuguese | Depressão | pt_BR |
Title | Is there a place for cellular therapy in depression? | pt_BR |
Type | Article | pt_BR |
DOI | 10.5498/wjp.v11.i9.553 | |
Abstract | Although efforts have been made to improve the pharmacological treatment of
depression, approximately one-third of patients with depression do not respond
to conventional therapy using antidepressants. Other potential non-pharmacological
therapies have been studied in the last years, including the use of
mesenchymal stem cell therapies to treat depression. These therapies are reviewed
here since it is clinically relevant to develop innovative therapeutics to treat
psychiatric patients. Experimental data corroborate that mesenchymal stem cell
therapy could be considered a potential treatment for depression based on its antiinflammatory
and neurotrophic properties. However, some clinical trials
involving treatment of depression with stem cells are in progress, but with no
published results. These studies and other future clinical investigations will be
crucial to define how much mesenchymal stem cells can effectively be used in
psychiatric clinics as a strategy for supporting depression treatment. | pt_BR |
Affilliation | Pontifical Catholic University of Rio Grande do Sul. Brain Institute of Rio Grande do Sul. Porto Alegre, RS, Brasil. | pt_BR |
Affilliation | Pontifical Catholic University of Rio Grande do Sul. Brain Institute of Rio Grande do Sul. Porto Alegre, RS, Brasil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education. Salvador, BA, Brazil. | pt_BR |
Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia de Tecidos e Imunofarmacologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Federal University of Santa Maria. Lab Health Sciences Center. Santa Maria, RS, Brazil. | pt_BR |
Subject | Mood disorders; | pt_BR |
Subject | Stem cells transplant; | pt_BR |
Subject | Mesenchymal stem-cells transplant; | pt_BR |
Subject | Inflammation; Immunomodulation; Depression | pt_BR |