Author | Paz, Lucas Nogueira | |
Author | Dias, Carla Silva | |
Author | Almeida, Daniela Santos | |
Author | Balassiano, Ilana Teruszkin | |
Author | Medeiros, Marco Alberto | |
Author | Cista, Federico | |
Author | Silva, Danielle Nascimento | |
Author | Reis, Joice Neves | |
Author | Lima, Alessandra Estrela | |
Author | Hamond, Camila | |
Author | Pinna, Melissa Hanzen | |
Access date | 2021-11-15T19:02:27Z | |
Available date | 2021-11-15T19:02:27Z | |
Document date | 2021 | |
Citation | PAZ, Lucas Nogueira et al. Multidisciplinary approach in the diagnosis of acute leptospirosis in dogs naturally infected by Leptospira interrogans serogroup Icterohaemorrhagiae: A prospective study. Comparative Immunology, Microbiology and Infectious Diseases, v. 77, 101664, p. 1-7, May 2021. | pt_BR |
ISSN | 0147-9571 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/49833 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Azotemia | pt_BR |
Subject in Portuguese | Canino | pt_BR |
Subject in Portuguese | Leptospirose | pt_BR |
Subject in Portuguese | Nefrite | pt_BR |
Title | Multidisciplinary approach in the diagnosis of acute leptospirosis in dogs naturally infected by Leptospira interrogans serogroup Icterohaemorrhagiae: A prospective study | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.cimid.2021.101664 | |
Abstract | Leptospirosis, a zoonotic disease with worldwide distribution, is caused by spirochetes of the genus Leptospira. In
dogs, this disease is frequently misdiagnosed. Few studies have attempted to associate the detection of Leptospira
spp. infection with clinicopathological and renal histopathological findings using a multidisciplinary approach.
The present study isolated and characterized Leptospira spp. obtained from naturally infected dogs and described
relevant clinical and histopathological findings. Blood and urine were collected from 57 dogs with clinical
symptomatology suggestive of leptospirosis; 38 cases were confirmed by PCR in urine or by culture or microscopic
agglutination testing (titers ≥800). A total of 12 strains of pathogenic Leptospira were isolated from the
studied dogs (seven in blood, four in urine and one in both blood and urine samples). All isolates were characterized
as Leptospira interrogans serogroup Icterohaemorrhagiae. Of the confirmed cases, almost one-third of
the animals had been vaccinated. Our analysis of laboratory testing revealed that azotemia and proteinuria were
statistically significant predictors of infection. The main histopathological findings seen in kidney tissues were
necrosis, degeneration, tubular regeneration, mononuclear inflammatory infiltrate and congestion. A multidisciplinary
approach involving clinicopathological and histopathological characterization of renal involvement can
aid in the identification of acute leptospirosis infection. | pt_BR |
Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Zootecnia nos Trópicos. Laboratório de Doenças Bacterianas. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Zootecnia nos Trópicos. Laboratório de Doenças Bacterianas. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Zootecnia nos Trópicos. Laboratório de Doenças Bacterianas. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Laboratório de Zoonoses Bacterianas. Centro de Referência Nacional de Leptospirose. Coleção de Leptospirose, Centro Colaborador da OMS / OPAS para Leptospirose. Rio de Janeiro, RJ, Brasil . | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos (BioManguinhos). Laboratório de Tecnologia Recombinante. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Institute of Integrative Biology, University of Liverpool. Liverpool, UK / Department of Epidemiology of Microbial Disease, Yale School of Public Health. New Haven, CT, USA. | pt_BR |
Affilliation | Universidade Federal da Bahia. Departamento de Anatomia, Patologia e Medicina Clínica Veterinária. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Escola de Farmácia. Departamento de Análise Clinica e Toxicológica. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Departamento de Anatomia, Patologia e Medicina Clínica Veterinária. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Zootecnia nos Trópicos. Laboratório de Doenças Bacterianas. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Programa de Pós-Graduação em Zootecnia nos Trópicos. Laboratório de Doenças Bacterianas. Salvador, BA, Brasil. | pt_BR |
Subject | Azotemia | pt_BR |
Subject | Canine | pt_BR |
Subject | Leptospirosis | pt_BR |
Subject | Nephritis | pt_BR |
Embargo date | 2023 | |