Author | Pereira, Evelyn Nunes Goulart da Silva | |
Author | Paula, Daniela Polessa | |
Author | Araujo, Beatriz Peres de | |
Author | Fonseca, Maria de Jesus Mendes da | |
Author | Diniz, Maria de Fátima Haueisen Sander | |
Author | Daliry, Anissa | |
Author | Griep, Rosane Harter | |
Access date | 2021-09-05T18:52:06Z | |
Available date | 2021-09-05T18:52:06Z | |
Document date | 2021 | |
Citation | PEREIRA, Evelyn Nunes Goulart da Silva et al. Advanced glycation end product: A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study. World Journal of Gastroenterology, v. 27, n. 29, p. 4913-4928, Aug. 2021. | pt_BR |
ISSN | 1007-9327 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/48992 | |
Language | eng | pt_BR |
Publisher | F6Publishing | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Produtos finais de glicação avançada | pt_BR |
Subject in Portuguese | Doença hepática gordurosa não alcoólica | pt_BR |
Subject in Portuguese | Esteatose | pt_BR |
Subject in Portuguese | Estudo ELSA-Brasil | pt_BR |
Subject in Portuguese | Espectroscopia | pt_BR |
Title | Advanced glycation end product: A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study | pt_BR |
Type | Article | pt_BR |
DOI | 10.3748/wjg.v27.i29.4913 | |
Abstract | BACKGROUND
Liver diseases are associated with the excess formation of advanced glycation end
products (AGEs), which induce tissue inflammation and oxidative damage.
However, the trend of oxidative marker levels according to the steatosis grade in
non-alcoholic fatty liver disease (NAFLD) is unclear.
AIM
To compare serum AGE levels between participants with NAFLD accordingly to
steatosis severity in the baseline ELSA-Brasil population.
METHODS
In 305 individuals at baseline ELSA-Brasil, NAFLD-associated steatosis was
classified by ultrasound hepatic attenuation. The participants were grouped
according to the severity of steatosis: mild and moderate/severe pooled. The
measurement of serum fluorescent AGE concentrations was based on spectro fluorimetric detection. Serum AGE content and clinical and laboratory character istics of the participants were compared between groups. The correlation between serum AGE levels and the grade of steatosis was analyzed. Logistic regression
analysis was used to investigate the relationship between serum AGE levels and
steatosis severity. A P value < 0.05 was considered statistically significant. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Brasileiro de Geografia e Estatística. Escola Nacional de Ciências Estatísticas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Advanced glycation end products | pt_BR |
Subject | Non-alcoholic fatty liver disease | pt_BR |
Subject | Steatosis | pt_BR |
Subject | ELSA-Brasil study | pt_BR |
Subject | Spectroscopy | pt_BR |
e-ISSN | 2219-2840 | |