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https://www.arca.fiocruz.br/handle/icict/48900
THE ROLE OF TRYPANOSOMA CRUZI AND ITS ANTIGENS ON THE PATHOGENESIS OF CHAGAS'S DISEASE MYOCARDIOPATHY
Miocarditis
Células dendríticas
Resposta celular
Resposta imune humoral
Andrade, Sonia Gumes | Date Issued:
2009
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunologia Celular. Salvador, BA, Brasil.
Abstract
Trypanosoma cruzi infection determines acute disease in the vertebrate host by the intracellular multiplication of parasites, especially within cardiac myocells, which is followed by parasitized host cell destruction and severe myocarditis. The parasite role during the acute phase is therefore evident. This form is followed by an asymptomatic indeterminate form that can be followed by a chronic myocardiopathy (20 - 35% of cases), with scarce parasites. Several authors have suggested an autoimmune mechanism for the chronic phase, with production of autoantibodies and auto-reactive T lymphocites. However, transference of such lymphocites to naïve mice has not met with success. We propose that interstitial dendric cells of the heart (antigens presenting cells) with captured, endocytosed and processed parasite antigens, migrate to the spleen where TCD4 (MHCII restrict) lymphocites are stimulated, inducing the cellular response in Chagas' disease myocarditis. Dendritic follicular cells in the spleen capture and present parasite antigens to splenic B lymphocites (humoral response) with maintenance of the immunological memory.
Keywords in Portuguese
Trypanosoma cruziMiocarditis
Células dendríticas
Resposta celular
Resposta imune humoral
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