Author | Bandeira, Larissa M. | |
Author | Puga, Marco A. M. | |
Author | Weis-Torres, Sabrina M. S. | |
Author | Rezende, Grazielli R. | |
Author | Domingos, João A. | |
Author | Tanaka, Tayana S. O. | |
Author | Cesar, Gabriela A. | |
Author | Nukui, Youko | |
Author | Vicente, Ana C. P. | |
Author | Casseb, Jorge | |
Author | Yamashiro, Juliana | |
Author | Segurado, Aluísio C. | |
Author | Salto, Murilo O. | |
Author | Pinho, João R. R. | |
Author | Cunha, Rivaldo V. | |
Author | Okumoto, Osnei | |
Author | Uehara, Silvia N. O. | |
Author | Castro, Ana R. C. Motta | |
Access date | 2021-08-02T19:17:29Z | |
Available date | 2021-08-02T19:17:29Z | |
Document date | 2021 | |
Citation | BANDEIRA, Larissa M. et al. Human T-cell leukemia virus type 1 infection among Japanese immigrants and their descendants living in Southeast Brazil: A call for preventive and control responses. Plos Negl Trop Dis., v. 15, n. 2, e0009066, 19 p, Feb. 2021. | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/48475 | |
Language | eng | pt_BR |
Publisher | Public Lybrary of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leucemia | pt_BR |
Subject in Portuguese | Infecção | pt_BR |
Subject in Portuguese | Vírus | pt_BR |
Subject in Portuguese | Células T humanas tipo 1 | pt_BR |
Subject in Portuguese | Imigrantes japoneses | pt_BR |
Subject in Portuguese | Sudeste do Brasil | pt_BR |
Subject in Portuguese | Chamadas | pt_BR |
Subject in Portuguese | Respostas preventivas e de controle | pt_BR |
Title | Human T-cell leukemia virus type 1 infection among Japanese immigrants and their descendants living in Southeast Brazil: A call for preventive and control responses | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pntd.0009066 | |
Abstract | Human T-cell leukemia virus type 1 (HTLV-1) has worldwide distribution and is considered
endemic in southwestern Japan. HTLV-1 infection has been associated with adult T-cell leu kemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis
(HAM/TSP) besides other diseases. This cross-sectional study aimed to investigate the
prevalence, risk factors and molecular characterization of HTLV-1, among the world’s larg est population of Japanese immigrants and their descendants outside of Japan, in São
Paulo, Southeast Brazil, as well as to analyze the phylogenetic relationship among isolates
of HTLV-1. From July to December 2017, 2,139 individuals from five Japanese associations
were interviewed and submitted to blood collection. All serum samples were first tested for
the presence of anti-HTLV-1/2 antibodies by ELISA and then peripheral blood from individu als with positive serological results were analyzed for the presence of HTLV-1 5’LTR proviral
DNA. Partial sequencing of the 5’LTR region of HTLV-1 proviral DNA was performed by
Sanger. The prevalence of HTLV-1 infection was 5.1% (CI 95%: 4.2–6.0). In the multiple
logistic regression model, HTLV-1 infection was associated with age � 45 years, female
sex, being first and second-generation Japanese immigrants, and having sexual partners
with history of blood transfusion. The phylogenetic analysis revealed that all HTLV-1 were
classified as Cosmopolitan (1a) subtype. Of them, 47.8% were classified as Transcontinen tal (A) subgroup and 52.2% as belonging to the Japanese (B) subgroup. Although most
HTLV-1-infected patients were asymptomatic (97.3%), blurred vision was associated with
HTLV-1 infection. The high prevalence of HTLV-1 infection found in this studied population
and especially the intra- and interfamily HTLV-1 transmission presents an urgent call for pre ventive and control responses of this infection in Brazil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Agência Mãe, São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Subject | Human T-cell leukemia | pt_BR |
Subject | Virus type 1 infection | pt_BR |
Subject | Japanese immigrants | pt_BR |
Subject | Southeast Brazil | pt_BR |
Subject | Preventive and control responses | pt_BR |
e-ISSN | 1935-2735 | |