Author | Szczupak, Diego | |
Author | Ferraz, Marina Kossmann | |
Author | Gemal, Lucas | |
Author | Szejnfeld, Patricia S. Oliveira | |
Author | Monteiro, Myriam | |
Author | Bramati, Ivanei | |
Author | Vargas, Fernando R. | |
Author | Roberto Lent, IRC5 Consortium | |
Author | Silva, Afonso C. | |
Author | Tovar-Moll, Fernanda | |
Access date | 2021-07-16T13:16:39Z | |
Available date | 2021-07-16T13:16:39Z | |
Document date | 2021 | |
Citation | SZCZUPAK, Diego et al. Corpus callosum dysgenesis causes novel patterns of structural and functional brain connectivity. Brain Communications, 2021, 11 p, 2021. | pt_BR |
ISSN | 1632-1297 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/48254 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Disgênese de Corpus calosum | pt_BR |
Subject in Portuguese | Novos padrões | pt_BR |
Subject in Portuguese | Cérebro estrutural | pt_BR |
Subject in Portuguese | Conectividade | pt_BR |
Title | Corpus callosum dysgenesis causes novel patterns of structural and functional brain connectivity | pt_BR |
Type | Article | |
DOI | 10.1093/braincomms/fcab057 | |
Abstract | Developmental malformations (dysgenesis) of the corpus callosum lead to neurological conditions with a broad range of clinical
presentations. Investigating the altered brain connectivity patterns is crucial to understanding both adaptive and maladaptive neu roplasticity in corpus callosum dysgenesis patients. Here, we acquired structural diffusion-weighted and resting-state functional
MRI data from a cohort of 11 corpus callosum dysgenesis patients (five with agenesis and six with hypoplasia) and compared their
structural and functional connectivity patterns to healthy subjects selected from the Human Connectome Project. We found that
these patients have fewer structural inter- and intra-hemispheric brain connections relative to healthy controls. Interestingly, the
patients with callosal agenesis have a scant number of inter-hemispheric connections but manage to maintain the full integrity of
functional connectivity between the same cortical regions as the healthy subjects. On the other hand, the hypoplasic group pre sented abnormal structural and functional connectivity patterns relative to healthy controls while maintaining the same total
amount of functional connections. These results demonstrate that acallosal patients can compensate for having fewer structural
brain connections and present functional adaptation. However, hypoplasics present atypical structural connections to different
brain regions, leading to entirely new and abnormal functional brain connectivity patterns. | pt_BR |
Affilliation | Department of Neurobiology, University of Pittsburgh Brain Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA. | pt_BR |
Affilliation | D’Or Institute of Research and Education (IDOR). Rio de Janeiro , RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Genética e Biologia Molecular. Rio de Janeiro , RJ, Brasil. | pt_BR |
Affilliation | D’Or Institute of Research and Education (IDOR). Rio de Janeiro , RJ, Brasil. | pt_BR |
Affilliation | D’Or Institute of Research and Education (IDOR). Rio de Janeiro , RJ, Brasil. | pt_BR |
Affilliation | D’Or Institute of Research and Education (IDOR). Rio de Janeiro , RJ, Brasil. | pt_BR |
Affilliation | D’Or Institute of Research and Education (IDOR). Rio de Janeiro , RJ, Brasil. | pt_BR |
Affilliation | D’Or Institute of Research and Education (IDOR). Rio de Janeiro , RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Genética e Biologia Molecular. Rio de Janeiro , RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. Rio de janeiro, RJ, Brasil. | pt_BR |
Affilliation | D’Or Institute of Research and Education (IDOR). Rio de Janeiro , RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Department of Neurobiology, University of Pittsburgh Brain Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA. | pt_BR |
Affilliation | D’Or Institute of Research and Education (IDOR). Rio de Janeiro , RJ, Brasil. | pt_BR |
Subject | Corpus callosum dysgenesis | pt_BR |
Subject | Novel patterns | pt_BR |
Subject | Connectivity | pt_BR |
Subject | Structural brain | pt_BR |
Embargo date | 2023 | |