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GENETIC EVIDENCE AND HOST IMMUNE RESPONSE IN PERSONS REINFECTED WITH SARS-COV-2, BRAZIL
SARS-CoV-2
Coronavirus disease
Humoral response
Next-generation sequencing
Reinfection
Respiratory infections
Severe acute respiratory syndrome coronavirus 2
Viruses
Zoonoses
Brazil
Author
Fintelman-Rodrigues, Natalia
Silva, Aline P. D. da
Santos, Monique Cristina dos
Saraiva, Felipe B.
Ferreira, Marcelo A.
Gesto, João
Rodrigues, Danielle A. S.
Vale, André M.
Azevedo, Isaclaudia G. de
Soares, Vinícius C.
Jiang, Hui
Tan, Hongdong
Tschoeke, Diogo A.
Sacramento, Carolina Q.
Bozza, Fernando A.
Morel, Carlos M.
Bozza, Patrícia T.
Souza, Thiago Moreno L.
Silva, Aline P. D. da
Santos, Monique Cristina dos
Saraiva, Felipe B.
Ferreira, Marcelo A.
Gesto, João
Rodrigues, Danielle A. S.
Vale, André M.
Azevedo, Isaclaudia G. de
Soares, Vinícius C.
Jiang, Hui
Tan, Hongdong
Tschoeke, Diogo A.
Sacramento, Carolina Q.
Bozza, Fernando A.
Morel, Carlos M.
Bozza, Patrícia T.
Souza, Thiago Moreno L.
Affilliation
Múltipla - Ver em Notas.
Abstract
The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.
Keywords
COVID-19SARS-CoV-2
Coronavirus disease
Humoral response
Next-generation sequencing
Reinfection
Respiratory infections
Severe acute respiratory syndrome coronavirus 2
Viruses
Zoonoses
Brazil
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