Author | Faria, Nieli Rodrigues da Costa | |
Author | Chaves Filho, Adriano Britto | |
Author | Alcantara, Luiz Carlos Junior | |
Author | Siqueira, Isadora Cristina de | |
Author | Calcagno, Juan Ignacio | |
Author | Miyamoto, Sayuri | |
Author | Filippis, Ana Maria Bispo de | |
Author | Yoshinaga, Marcos Yukio | |
Access date | 2021-06-17T12:12:26Z | |
Available date | 2021-06-17T12:12:26Z | |
Document date | 2021 | |
Citation | FARIA, Nieli Rodrigues da Costa et al. Plasma lipidome profiling of newborns with antenatal exposure to Zika virus. PLoS Neglected Tropical Diseases, v. 15, n. 4, p. 1-16, 30 Apr. 2021. | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/47738 | |
Sponsorship | Coordenação de Vigilância em Saúde e Laboratórios de Referência, Brazilian Ministry of Health (CVSRL-Fiocruz to AMBF) | pt_BR |
Sponsorship | Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ, grant number E-26/2002.930/2016 to AMBF) | pt_BR |
Sponsorship | Horizon 2020 through ZikaPlan and ZikAction (grant agreement numbers 734584 and 734857) | pt_BR |
Sponsorship | International Development Research Centre Canada (IDRC, 108411-001 to AMBF) | pt_BR |
Sponsorship | National Council for Scientific and Technological Development (CNPq, 440685/2016-8 and 443875/2018 to ICS) | pt_BR |
Sponsorship | São Paulo Research Foundation (FAPESP, CEPID-Redoxoma 2013/07937–8 to SM) | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | |
Subject in Portuguese | Lipídeos | pt_BR |
Subject in Portuguese | Zika Vírus | pt_BR |
Subject in Portuguese | Microcefalia | pt_BR |
Subject in Portuguese | Plasma sanguíneo | pt_BR |
Subject in Portuguese | Ácidos graxos | pt_BR |
Subject in Portuguese | Análise lipídica | pt_BR |
Subject in Portuguese | Recém-nascidos | pt_BR |
Subject in Portuguese | Isômeros | pt_BR |
Title | Plasma lipidome profiling of newborns with antenatal exposure to Zika virus | en |
Type | Article | |
DOI | 10.1371/journal.pntd.0009388 | pt_BR |
Abstract | The 2015–2016 Zika virus (ZIKV) outbreak in Brazil was remarkably linked to the incidence of microcephaly and other deleterious clinical manifestations, including eye abnormalities, in newborns. It is known that ZIKV targets the placenta, triggering an inflammatory profile that may cause placental insufficiency. Transplacental lipid transport is delicately regulated during pregnancy and deficiency on the delivery of lipids such as arachidonic and docosahexaenoic acids may lead to deficits in both brain and retina during fetal development. Here, plasma lipidome profiles of ZIKV exposed microcephalic and normocephalic newborns were compared to non-infected controls. Our results reveal major alterations in circulating lipids from both ZIKV exposed newborns with and without microcephaly relative to controls. In newborns with microcephaly, the plasma concentrations of hydroxyoctadecadienoic acid (HODE), primarily as 13-HODE isomer, derived from linoleic acid were higher as compared to normocephalic ZIKV exposed newborns and controls. Total HODE concentrations were also positively associated with levels of other oxidized lipids and several circulating free fatty acids in newborns, indicating a possible plasma lipidome signature of microcephaly. Moreover, higher concentrations of lysophosphatidylcholine in ZIKV exposed normocephalic newborns relative to controls suggest a potential disruption of polyunsaturated fatty acids transport across the blood-brain barrier of fetuses. The latter data is particularly important given the neurocognitive and neurodevelopmental abnormalities observed in follow-up studies involving children with antenatal ZIKV exposure, but normocephalic at birth. Taken together, our data reveal that plasma lipidome alterations associated with antenatal exposure to ZIKV could contribute to identification and monitoring of the wide spectrum of clinical phenotypes at birth and further, during childhood. | en |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Governo do Estado. Secretaria da Saúde. Maternidade José Maria de Magalhães Netto. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil. | pt_BR |
Subject | Lipids | en |
Subject | Zika Virus | en |
Subject | Microcephaly | en |
Subject | Blood plasma | en |
Subject | Fatty acids | en |
Subject | Lipid analysis | en |
Subject | Neonates | en |
Subject | Isomers | en |
e-ISSN | 1935-2735 | pt_BR |