Author | Costa-Filho, Rubens Carmo | |
Author | Castro-Faria Neto, Hugo Caire | |
Author | Mengel, José | |
Author | Pelajo-Machado, Marcelo | |
Author | Martins, Marco Aurélio | |
Author | Leite, Érica Távora | |
Author | Mendonça-Filho, Hugo Tannus | |
Author | Souza, Tatiana de Arruda Campos Brasil de | |
Author | Bentacor, Gonzalo Bello | |
Author | Leite, José Paulo Gagliardi | |
Access date | 2021-06-16T19:01:30Z | |
Available date | 2021-06-16T19:01:30Z | |
Document date | 2021 | |
Citation | COSTA-FILHO, Rubens Carmo et al. Should COVID-19 be branded to viral thrombotic fever? Mem Inst. Oswaldo Cruz, n. 116, p. 1–8, 2021. | pt_BR |
ISSN | 1678-8060 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/47732 | |
Language | por | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Title | Should COVID-19 be branded to viral thrombotic fever? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760200552 | |
Abstract | Coronaviruses can cause a diverse array of clinical manifestations, from fever with symptoms of the common cold to highly lethal severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS). SARS-CoV-2, the coronavirus discovered in Hubei province, China, at the end of 2019, became known worldwide for causing coronavirus disease 2019 (COVID-19). Over one year’s time period, the scientific community has produced a large bulk of knowledge about this disease and countless reports about its immune-pathological aspects. This knowledge, including data obtained in postmortem studies, points unequivocally to a hypercoagulability state. However, the name COVID-19 tells us very little about the true meaning of the disease. Our proposal is more comprehensive; it intends to frame COVID-19 in more clinical terminology, making an analogy to viral haemorrhagic fever (VHF). Thus, we found irrefutable evidence in the current literature that COVID-19 is the first viral
disease that can be branded as a viral thrombotic fever. This manuscript points out that SARS-CoV-2 goes far beyond pneumonia or SARS. COVID-19 infections promote remarkable interactions among the endothelium, coagulation, and immune response, building up a background capable of promoting a “thrombotic storm,” much more than a “cytokine storm.” The importance of a viral protease called main protease (Mpro) is highlighted as a critical component for its replication in the host cell. A deeper analysis of this protease and its importance on the coagulation system is also discussed for the first time, mainly because of its similarity with the thrombin and factor Xa molecules, as recently pointed out by structural comparison crystallographic structures. | pt_BR |
Affilliation | Hospital Pró-Cardíaco. Founder and coordinator of Department of Critical Care. Americas Medical Services. United Health Group. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / UNIFASE. Faculdade de Medicina. Petrópolis, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Nacional do Câncer. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Políticas de Saúde – UHG (UnitedHealth Group). Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Endothelium | pt_BR |
Subject | SARS CoV 2 Infection | pt_BR |
Subject | Coronavirus 3C Proteases | pt_BR |
Subject | Inflammation | pt_BR |
Subject | Blood Coagulation | pt_BR |
Subject | Thrombosis | pt_BR |
Subject | Thrombelastography | pt_BR |
Subject in Spanish | Endotelio | pt_BR |
Subject in Spanish | Proteasas 3C de Coronavirus | pt_BR |
Subject in Spanish | Inflamación | pt_BR |
Subject in Spanish | Coagulación Sanguínea | pt_BR |
Subject in Spanish | Trombosis | pt_BR |
Subject in Spanish | Tromboelastografía | pt_BR |
Subject in French | Endothélium | pt_BR |
Subject in French | Inflammation | pt_BR |
Subject in French | Coagulation sanguine | pt_BR |
Subject in French | Thrombose | pt_BR |
Subject in French | Thromboélastographie | pt_BR |
DeCS | Endotélio | pt_BR |
DeCS | COVID-19 | pt_BR |
DeCS | SARS-CoV-2 | pt_BR |
DeCS | Proteína Mpro de Coronavírus | pt_BR |
DeCS | Inflamação | pt_BR |
DeCS | Coagulação Sanguínea | pt_BR |
DeCS | Trombose | pt_BR |
DeCS | Tromboelastografia | pt_BR |