Author | Figueiredo, Camylla Vilas Boas | pt_BR |
Author | Santiago, Rayra Pereira | pt_BR |
Author | Guarda, Caroline Conceição da | pt_BR |
Author | Oliveira, Rodrigo Mota | pt_BR |
Author | Fiuza, Luciana Magalhães | pt_BR |
Author | Yahouédéhou, Sètondji Cocou Modeste Alexandre | pt_BR |
Author | Carvalho, Suéllen Pinheiro | pt_BR |
Author | Neres, Joelma Santana dos Santos | pt_BR |
Author | Oliveira, Antonio Mateus de Jesus | pt_BR |
Author | Fonseca, Cleverson Alves | pt_BR |
Author | Nascimento, Valma Maria Lopes | pt_BR |
Author | Lyra, Isa Menezes | pt_BR |
Author | Aleluia, Milena Magalhães | pt_BR |
Author | Goncalves, Marilda de Souza | pt_BR |
Access date | 2021-06-16T17:42:56Z | |
Available date | 2021-06-16T17:42:56Z | |
Document date | 2021 | |
Citation | FIGUEIREDO, Camylla Vilas Boas et al. Priapism in sickle cell disease: associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers. PLoS ONE, p. 1-15, 4 Feb. 2021. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/47724 | |
Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 470959/2014-2 and 405595/2016-6) | pt_BR |
Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES), Finance Code 001 | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Transfusão de sangue | pt_BR |
Subject in Portuguese | Hemoglobina | pt_BR |
Subject in Portuguese | Alelos | pt_BR |
Subject in Portuguese | Biomarcadores | pt_BR |
Subject in Portuguese | Sangue | pt_BR |
Subject in Portuguese | Óxido nítrico | pt_BR |
Subject in Portuguese | Análise multivariada | pt_BR |
Subject in Portuguese | Genótipos variantes | pt_BR |
Title | Priapism in sickle cell disease: associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers | en |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0246067 | pt_BR |
Abstract | Priapism is a urologic emergency characterized by an uncontrolled, persistent and painful erection in the absence of sexual stimulation, which can lead to penile fibrosis and impotence. It is highly frequent in sickle cell disease (SCD) associated with hemolytic episodes. Our aim was to investigate molecules that may participate in the regulation of vascular tone. Eighty eight individuals with SCD were included, of whom thirty-seven reported a history of priapism. Priapism was found to be associated with alterations in laboratory biomarkers, as well as lower levels of HbF. Patients with sickle cell anemia using hydroxyurea and those who received blood products seemed to be less affected by priapism. Multivariate analysis suggested that low HbF and NOm were independently associated with priapism. The frequency of polymorphisms in genes NOS3 and EDN1 was not statistically significant between the studied groups, and the presence of the variant allele was not associated with alterations in NOm and ET-1 levels in patients with SCD. The presence of the variant allele in the polymorphisms investigated did not reveal any influence on the occurrence priapism. Future studies involving larger samples, as well as investigations including patients in priapism crisis, could contribute to an enhanced understanding of the development of priapism in SCD. | en |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Secretaria da Saúde do Estado da Bahia. Fundação de Hematologia e Hemoterapia do Estado da Bahia. Salvador, BA, Brasil., | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Subject | Blood transfusion | en |
Subject | Hemoglobin | en |
Subject | Alleles | en |
Subject | Biomarkers | en |
Subject | Blood | en |
Subject | Nitric oxide | en |
Subject | Multivariate analysis | en |
Subject | Variant genotypes | en |