Author | Xavier, Jadriane de Almeida | |
Author | Silva, Thaissa L. | |
Author | Santos, Eduardo Caio Torres | |
Author | Vasconcelos, Camila Calado de | |
Author | Boane, Anastacio | |
Author | Santos, Ricardo Alexandre dos | |
Author | Xavier, Andre Felippe A. | |
Author | Goulart, Marília O. F | |
Access date | 2021-05-03T13:14:34Z | |
Available date | 2021-05-03T13:14:34Z | |
Document date | 2021 | |
Citation | XAVIER, Jadriane de Almeida et al. Unveiling the relevance of the redox character of nitroaromatic and nitroheteroaromatic compounds as potential medicines. Current Opinion in Electrochemistry, online xxx 10p, 2021. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/47014 | |
Language | eng | pt_BR |
Publisher | Science Direct | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Estresse oxidativo | pt_BR |
Subject in Portuguese | Alquilação biorredutiva | pt_BR |
Subject in Portuguese | Nitroreductases | pt_BR |
Subject in Portuguese | Mecanismo molecular de ação | pt_BR |
Subject in Portuguese | Metabolismo | pt_BR |
Subject in Portuguese | Electrochemical parameters | pt_BR |
Title | Unveiling the relevance of the redox character of nitroaromatic and nitroheteroaromatic compounds as Q6 potential medicines | pt_BR |
Type | Preprint | pt_BR |
Abstract | This review discusses the state of the art, challenges, and
perspectives in recent applications of nitroaromatics and
nitroheteroaromatics, which are redox-bio-activated drugs or
leads, in Medicinal Chemistry. It deals mainly with the elec trochemical approach toward the electron transfer-based mo lecular mechanisms of drug action, drug design, estimation
and measurement of redox potentials, correlation of physico chemical and pharmacological data, and electrochemical
studies of the main representatives of nitro-containing
prodrugs, along with approaches to combat their toxicity
issues, aiming at a better therapeutic profile. Electrochemical
investigation plays essential roles, being strategic in the design
and discovery of potential medicines. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil / Universidade Federal de Alagoas. Núcleo de Ciências Exatas – NCEx. Campus de Arapiraca, Al, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil / Centro Universitário CESMAC. Maceió, AL, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
Subject | Oxidative stress | pt_BR |
Subject | Bioreductive alkylation | pt_BR |
Subject | Nitroreductases | pt_BR |
Subject | Molecular mechanism of action | pt_BR |
Subject | Metabolism | pt_BR |
Subject | Electrochemical parameters | pt_BR |
Embargo date | 2023 | |