Author | Benseñor, Isabela M. | |
Author | Sgarbi, José Augusto | |
Author | Janovsky, Carolina Castro Porto Silva | |
Author | Pittita, Bianca Almeida | |
Author | Diniz, Maria de Fátima Haueisen Sander | |
Author | Almeida, Maria da Conceição Chagas de | |
Author | Alvim, Sheila Maria | |
Author | Barreto, Sandhi M. | |
Author | Giatti, Luana | |
Author | Duncan, Bruce B. | |
Author | Schmidt, Maria Inês | |
Author | Fonseca, Maria de Jesus M. | |
Author | Griep, Rosane H. | |
Author | Molina, Maria del Carmen B. | |
Author | Mill, João Geraldo | |
Author | Santos, Itamar de Souza | |
Author | Goulart, Alesandra C. | |
Author | Lotudo, Paulo A. | |
Access date | 2021-04-30T19:21:39Z | |
Available date | 2021-04-30T19:21:39Z | |
Document date | 2021 | |
Citation | BENSEÑOR, Isabela M. et al. Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Arch Endocrinol Metab. Online ahead of print, 11p, 2021. | pt_BR |
ISSN | 2359-3997 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46989 | |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira de Endocrinologia e Metabologia | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Overt thyroid diseases | pt_BR |
Subject in Portuguese | ELSA-Brasil | pt_BR |
Subject in Portuguese | Doenças da tireoide subclínica | pt_BR |
Subject in Portuguese | Hipertiroidismo | pt_BR |
Subject in Portuguese | Hipotireoidismo | pt_BR |
Subject in Portuguese | Incidência | pt_BR |
Title | Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) | pt_BR |
Type | Article | pt_BR |
DOI | 10.20945/2359-3997000000348 | |
Abstract | Objective: To evaluate incidence of subclinical and overt hyperthyroidism and hypothyroidism. Subjects
and methods: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study
of 15,105 civil servants, examined at baseline and over a 4-year follow-up. This analysis included 9,705
participants with normal thyroid function at baseline, follow-up information about thyroid function and
with no report of using drugs that may interfere in the thyroid function. Thyroid function was defined by
TSH/FT4 levels or routine use of thyroid hormones/anti-thyroid medications. Annual and cumulative (over
4-year) incidence rates were presented as percentages (95% Confidence Intervals). Results: The incidence
of all overt and subclinical thyroid disease was 6.7% (1.73%/year): 0.19% for overt hyperthyroidism (0.048%/
year), 0.54% for subclinical hyperthyroidism (0.14%/year), 1.98% for overt hypothyroidism (0.51%/year),
and 3.99% for subclinical hypothyroidism (1.03%/year). The incidence of all thyroid diseases was higher in
women, when compared to men, with a low women:men ratio (1.36). For Blacks the highest incidence was
for overt hyperthyroidism, while for Whites, the highest incidence was for overt hypothyroidism. However,
the highest incidence of overt hyperthyroidism was detected in Asian descendants. The presence of
antithyroperoxidase antibodies at baseline was associated with higher incidence of overt thyroid diseases.
Conclusions: These results showed a high incidence of hypothyroidism, which is compatible with a
country with a more-than-adequate iodine intake. The low women:men ratio of the incidence of thyroid
dysfunction highlights the importance of the diagnosis of thyroid diseases among men in Brazil. | pt_BR |
Affilliation | Universidade de São Paulo, São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Faculdade de Medicina de Marília. Divisão de Endocrinologia. Marília, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Medicina Preventiva. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Medicina Preventiva. Belho Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Medicina Preventiva. Belho Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Escola Nacional de saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Saúde e Meio Ambiente. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Departamento de Nutrição. Vitória, ES, Brasil. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo, São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo, São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo, São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
Subject | Overt thyroid diseases | pt_BR |
Subject | Subclinical thyroid diseases | pt_BR |
Subject | Hyperthyroidism | pt_BR |
Subject | Hypothyroidism | pt_BR |
Subject | Incidence | pt_BR |
Subject | ELSA-Brasil | pt_BR |
e-ISSN | 2359-4292 | |